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Status: Bibliographieeintrag

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Verfasst von:Berhe, Oksana [VerfasserIn]   i
 Höflich, Anna [VerfasserIn]   i
 Mößnang, Carolin Ulrike [VerfasserIn]   i
 Reichert, Markus [VerfasserIn]   i
 Kremer, Thomas [VerfasserIn]   i
 Gan, Gabriela [VerfasserIn]   i
 Ma, Ren [VerfasserIn]   i
 Braun, Urs [VerfasserIn]   i
 Reininghaus, Ulrich [VerfasserIn]   i
 Ebner-Priemer, Ulrich [VerfasserIn]   i
 Meyer-Lindenberg, Andreas [VerfasserIn]   i
 Tost, Heike [VerfasserIn]   i
Titel:Reduced real-life affective well-being and amygdala habituation in unmedicated community individuals at risk for depression and anxiety
Verf.angabe:Oksana Berhe, Anna Höflich, Carolin Moessnang, Markus Reichert, Thomas Kremer, Gabriela Gan, Ren Ma, Urs Braun, Ulrich Reininghaus, Ulrich Ebner-Priemer, Andreas Meyer-Lindenberg, and Heike Tost
E-Jahr:2023
Jahr:January 2023
Umfang:10 S.
Illustrationen:Illustrationen
Fussnoten:Online verfügbar: 24. Juni 2022, Artikelversion: 5. Januar 2023 ; Gesehen am 23.08.2023
Titel Quelle:Enthalten in: Biological psychiatry. Cognitive neuroscience and neuroimaging
Ort Quelle:Amsterdam [u.a.] : Elsevier Inc., 2016
Jahr Quelle:2023
Band/Heft Quelle:8(2023), 1 vom: Jan., Seite 111-120
ISSN Quelle:2451-9030
Abstract:Background - Early identification of risk for depression and anxiety disorders is important for prevention, but real-life affective well-being and its biological underpinnings in the population remain understudied. Here, we combined methods from epidemiology, psychology, ecological momentary assessment, and functional magnetic resonance imaging to study real-life and neural affective functions in individuals with subclinical anxiety and depression from a population-based cohort of young adults. - Methods - We examined psychological measures, real-life affective valence, functional magnetic resonance imaging amygdala habituation to negative affective stimuli, and the relevance of neural readouts for daily-life affective function in 132 non-help-seeking community individuals. We compared psychological and ecological momentary assessment measures of 61 unmedicated individuals at clinical risk for depression and anxiety (operationalized as subthreshold depression and anxiety symptoms or a former mood or anxiety disorder) with those of 48 nonrisk individuals and 23 persons with a mood or anxiety disorder. We studied risk-associated functional magnetic resonance imaging signals in subsamples with balanced sociodemographic and image quality parameters (26 nonrisk, 26 at-risk persons). - Results - Compared with nonrisk persons, at-risk individuals showed significantly decreased real-life affective valence (p = .038), reduced amygdala habituation (familywise error-corrected p = .024, region of interest corrected), and an intermediate psychological risk profile. Amygdala habituation predicted real-life affective valence in control subjects but not in participants at risk (familywise error-corrected p = .005, region of interest corrected). - Conclusions - Our data suggest real-life and neural markers for affective alterations in unmedicated community individuals at risk for depression and anxiety and highlight the significance of amygdala habituation measures for the momentary affective experience in real-world environments.
DOI:doi:10.1016/j.bpsc.2022.06.009
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.bpsc.2022.06.009
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2451902222001537
 DOI: https://doi.org/10.1016/j.bpsc.2022.06.009
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Anxiety disorders
 Community sample
 Ecologic momentary assessment
 Functional neuroimaging
 Major depression
 Mental health risk
K10plus-PPN:1857662504
Verknüpfungen:→ Zeitschrift

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