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| Verfasst von: | Moratin, Julius [VerfasserIn]  |
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| | Zittel, Sven [VerfasserIn] |
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| | Horn, Dominik [VerfasserIn] |
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| | Behnisch, Rouven [VerfasserIn] |
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| | Ristow, Oliver [VerfasserIn] |
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| | Engel, Michael [VerfasserIn] |
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| | Hoffmann, Jürgen [VerfasserIn] |
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| | Freier, Kolja [VerfasserIn] |
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| | Freudlsperger, Christian [VerfasserIn] |
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| Titel: | Free-flap reconstruction in early-stage squamous cell carcinoma of the oral cavity - a prospective monocentric trial to evaluate oncological outcome and quality of life |
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| Verf.angabe: | Julius Moratin, Sven Zittel, Dominik Horn, Rouven Behnisch, Oliver Ristow, Michael Engel, Jürgen Hoffmann, Kolja Freier and Christian Freudlsperger |
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| Jahr: | 2023 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Veröffentlicht: 22. Juli 2023 ; Gesehen am 24.08.2023 |
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| Titel Quelle: | Enthalten in: Journal of Clinical Medicine |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 12(2023), 14, Artikel-ID 4833, Seite 1-12 |
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| ISSN Quelle: | 2077-0383 |
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| Abstract: | Surgery is generally accepted as standard treatment in oral cancer, but the reconstructive procedures remain a matter of debate. The aim of this study was to evaluate oncological outcome and quality of life following surgical resection and free-flap reconstruction in patients with early oral squamous cell carcinoma. The presented trial was performed as a prospective, single-center observation study. Inclusion criteria were primary surgery in early-stage oral squamous cell carcinoma with free-flap reconstruction. Endpoints were overall and progression-free survival and quality of life up to 24 months after surgery. Twenty-six patients were included. Overall survival was 100% and progression-free survival was 92.3% in a maximum follow-up time of 21 months. Global quality of life showed no significant alteration after surgery. Patients reported a significant reduction in pain (p = 0.048) and a decreasing impairment of speech one year after surgery (p = 0.021). Free-flap reconstruction is a safe procedure that results in excellent oncological outcome and quality of life. Functional outcome is of high relevance in early-stage tumors of the head and neck and may mostly be affected by reconstructive procedures. Therefore, a prospective evaluation to explore success and the effects of surgical therapy is highly warranted. |
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| DOI: | doi:10.3390/jcm12144833 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/jcm12144833 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2077-0383/12/14/4833 |
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| | DOI: https://doi.org/10.3390/jcm12144833 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | early oral squamous cell carcinoma |
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| | free flap |
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| | microvascular reconstruction |
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| | quality of life |
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| | survival |
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| K10plus-PPN: | 1857872231 |
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| Verknüpfungen: | → Zeitschrift |
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Free-flap reconstruction in early-stage squamous cell carcinoma of the oral cavity - a prospective monocentric trial to evaluate oncological outcome and quality of life / Moratin, Julius [VerfasserIn]; 2023 (Online-Ressource)
