The molecular evolution of mammalian spermatogenesis

• Verfasst von: Trost, Nils [VerfasserIn]
• Verfasst von: Mbengue, Noe [VerfasserIn]
• Verfasst von: Kaessmann, Henrik [VerfasserIn]
• Titel: The molecular evolution of mammalian spermatogenesis
• Verf.angabe: Nils Trost, Noe Mbengue, Henrik Kaessmann
• E-Jahr: 2023
• Jahr: September 2023
• Umfang: 8 S.
• Fussnoten: Online verfügbar: 17. Juni 2023, Artikelversion: 20. Juni 2023 ; Gesehen am 24.08.2023
• Titel Quelle: Enthalten in: Cells & development
• Ort Quelle: Amsterdam : Elsevier, 2021
• Jahr Quelle: 2023
• Band/Heft Quelle: 175(2023) vom: Sept., Artikel-ID 203865, Seite 1-8
• ISSN Quelle: 2667-2901
• DOI: doi:10.1016/j.cdev.2023.203865
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Male germ cells
• Sach-SW: Mammals
• Sach-SW: Molecular evolution
• Sach-SW: Spermatogenesis
• Sach-SW: Spermatogonial stem cells
• Sach-SW: Testis
• K10plus-PPN: 1857879090

Abstract

The testis is a key male reproductive organ that produces gametes through the process of spermatogenesis. Testis morphologies, sperm phenotypes, and the process of spermatogenesis evolve rapidly in mammals, presumably due to the evolutionary pressure on males to give rise to their own offspring. Here, we review studies illuminating the molecular evolution of the testis, in particular large-scale transcriptomic studies, which were based on bulk tissue samples and, more recently, individual cells. Together with various genomic and epigenomic data, these studies have unveiled the cellular source, molecular mechanisms, and evolutionary forces that underlie the rapid phenotypic evolution of the testis. They also revealed shared (ancestral) and species-specific spermatogenic gene expression programs. The insights and available data that have accumulated also provide a valuable resource for the investigation and treatment of male fertility disorders - a dramatically increasing problem in modern industrial societies.