Same-day repeatability and between-sequence reproducibility of mean ADC in PI-RADS lesions

• Verfasst von: Zhang, Kevin Sun [VerfasserIn]
• Verfasst von: Neelsen, Christian [VerfasserIn]
• Verfasst von: Wennmann, Markus [VerfasserIn]
• Verfasst von: Glemser, Philip [VerfasserIn]
• Verfasst von: Hielscher, Thomas [VerfasserIn]
• Verfasst von: Weru, Vivienn [VerfasserIn]
• Verfasst von: Görtz, Magdalena [VerfasserIn]
• Verfasst von: Schütz, Viktoria [VerfasserIn]
• Verfasst von: Stenzinger, Albrecht [VerfasserIn]
• Verfasst von: Hohenfellner, Markus [VerfasserIn]
• Verfasst von: Schlemmer, Heinz-Peter [VerfasserIn]
• Verfasst von: Bonekamp, David [VerfasserIn]
• Titel: Same-day repeatability and between-sequence reproducibility of mean ADC in PI-RADS lesions
• Verf.angabe: Kevin Sun Zhang, Christian Jan Oliver Neelsen, Markus Wennmann, Philipp Alexander Glemser, Thomas Hielscher, Vivienn Weru, Magdalena Görtz, Viktoria Schütz, Albrecht Stenzinger, Markus Hohenfellner, Heinz-Peter Schlemmer, David Bonekamp
• E-Jahr: 2023
• Jahr: August 2023
• Umfang: 11 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 8. Juni 2023, Artikelversion: 16. Juni 2023 ; Gesehen am 25.08.2023
• Titel Quelle: Enthalten in: European journal of radiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1990
• Jahr Quelle: 2023
• Band/Heft Quelle: 165(2023) vom: Aug., Artikel-ID 110898, Seite 1-11
• ISSN Quelle: 1872-7727
• DOI: doi:10.1016/j.ejrad.2023.110898
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ADC
• Sach-SW: Apparent diffusion coefficient
• Sach-SW: Prostate
• Sach-SW: Repeatability
• Sach-SW: Reproducibility
• Sach-SW: Retest
• Sach-SW: Stability
• Sach-SW: Test
• K10plus-PPN: 1857979559

Abstract

Purpose - This study aimed to assess repeatability after repositioning (inter-scan), intra-rater, inter-rater and inter-sequence variability of mean apparent diffusion coefficient (ADC) measurements in MRI-detected prostate lesions. - Method - Forty-three patients with suspicion for prostate cancer were included and received a clinical prostate bi-/multiparametric MRI examination with repeat scans of the T2-weighted and two DWI-weighted sequences (ssEPI and rsEPI). Two raters (R1 and R2) performed single-slice, 2D regions of interest (2D-ROIs) and 3D-segmentation-ROIs (3D-ROIs). Mean bias, corresponding limits of agreement (LoA), mean absolute difference, within-subject coefficient of variation (CoV) and repeatability/reproducibility coefficient (RC/RDC) were calculated. Bradley & Blackwood test was used for variance comparison. Linear mixed models (LMM) were used to account for multiple lesions per patient. - Results - Inter-scan repeatability, intra-rater and inter-sequence reproducibility analysis of ADC showed no significant bias. 3D-ROIs demonstrated significantly less variability than 2D-ROIs (p < 0.01). Inter-rater comparison demonstrated small significant systematic bias of 57 × 10-6 mm2/s for 3D-ROIs (p < 0.001). Intra-rater RC, with the lowest variation, was 145 and 189 × 10-6 mm2/s for 3D- and 2D-ROIs, respectively. For 3D-ROIs of ssEPI, RCs and RDCs were 190-198 × 10-6 mm2/s for inter-scan, inter-rater and inter-sequence variation. No significant differences were found for inter-scan, inter-rater and inter-sequence variability. - Conclusions - In a single-scanner setting, single-slice ADC measurements showed considerable variation, which may be lowered using 3D-ROIs. For 3D-ROIs, we propose a cut-off of ∼ 200 × 10-6 mm2/s for differences introduced by repositioning, rater or sequence effects. The results suggest that follow-up measurements should be possible by different raters or sequences.