| Online-Ressource |
Verfasst von: | Möhl, Annika [VerfasserIn]  |
| Behrens, Sabine [VerfasserIn]  |
| Flaßkamp, Fabian [VerfasserIn]  |
| Obi, Nadia [VerfasserIn]  |
| Kreienbrinck, Annika [VerfasserIn]  |
| Holleczek, Bernd [VerfasserIn]  |
| Gali, Kathleen [VerfasserIn]  |
| Chang-Claude, Jenny [VerfasserIn]  |
| Becher, Heiko [VerfasserIn]  |
Titel: | The impact of cardiovascular disease on all-cause and cancer mortality |
Titelzusatz: | results from a 16-year follow-up of a German breast cancer case-control study |
Verf.angabe: | Annika Möhl, Sabine Behrens, Fabian Flaßkamp, Nadia Obi, Annika Kreienbrinck, Bernd Holleczek, Kathleen Gali, Jenny Chang-Claude and Heiko Becher |
Jahr: | 2023 |
Umfang: | 9 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Veröffentlicht: 27. Juli 2023 ; Gesehen am 28.08.2023 |
Titel Quelle: | Enthalten in: Breast cancer research |
Ort Quelle: | London : BioMed Central, 1999 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 25(2023), Artikel-ID 89, Seite 1-9 |
ISSN Quelle: | 1465-542X |
Abstract: | Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. The aim of this study was to examine if CVD affects the mortality of women after a breast cancer diagnosis and population controls differently. Methods: The analysis included a total of 3,555 women, diagnosed with primary stage 1–3 breast cancer or in situ carcinoma between 2002 and 2005 and 7,334 controls breast cancer-free at recruitment, all aged 50–74 years, who were followed-up in a German breast cancer case–control study until June, 30 2020. Kaplan–Meier and cumulative incidence function were calculated for all-cause mortality and mortality from any cancer, stratified for case–control status and CVD, separately for women aged < 65 and ≥ 65 years. Cox regression and Fine-Gray subdistribution hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between case–control-status, CVD and mortality from all causes/any cancer. Results: The median follow-up was 16.1 years. In total, 1,172 cases (33.0%) and 1,401 initial controls (19.1%) died. CVD prevalence at recruitment was 15.2% in cases and controls. Cases with CVD had the highest and controls without CVD the lowest mortality during the entire observation period in both age groups (< 65 and ≥ 65 years). CVD was identified as a risk factor for all-cause mortality in both cases and controls aged < 65 years (HR 1.22, 95%CI 0.96–1.55 and HR 1.79, 95%CI 1.43–2.24) as well as at ages of ≥ 65 years (HR 1.44, 95%CI 1.20–1.73 and HR 1.59, 95%CI 1.37–1.83). A significant association of CVD and cancer mortality was found only for cases aged ≥ 65 years. Conclusion: CVD was significantly associated with all-cause mortality of both cases and controls and CVD was identified as a risk factor for cancer mortality of cases aged ≥ 65 years at recruitment. Therefore, attention should be paid on monitoring and preventing CVD in breast cancer patients, especially in those diagnosed at older ages. |
DOI: | doi:10.1186/s13058-023-01680-x |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1186/s13058-023-01680-x |
| DOI: https://doi.org/10.1186/s13058-023-01680-x |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Breast cancer |
| Cardiovascular disease |
| Case-control study |
| Mortality |
K10plus-PPN: | 1858045126 |
Verknüpfungen: | → Zeitschrift |
¬The¬ impact of cardiovascular disease on all-cause and cancer mortality / Möhl, Annika [VerfasserIn]; 2023 (Online-Ressource)