Role of diabetes in collateral status assessed in CT perfusion-derived dynamic CTA in anterior circulation stroke

• Verfasst von: Scheidecker, Emilia [VerfasserIn]
• Verfasst von: Pereira-Zimmermann, Benjamin [VerfasserIn]
• Verfasst von: Potreck, Arne [VerfasserIn]
• Verfasst von: Vollherbst, Dominik [VerfasserIn]
• Verfasst von: Möhlenbruch, Markus Alfred [VerfasserIn]
• Verfasst von: Gumbinger, Christoph [VerfasserIn]
• Verfasst von: Bendszus, Martin [VerfasserIn]
• Verfasst von: Herweh, Christian [VerfasserIn]
• Verfasst von: Seker, Fatih [VerfasserIn]
• Titel: Role of diabetes in collateral status assessed in CT perfusion-derived dynamic CTA in anterior circulation stroke
• Verf.angabe: Emilia Scheidecker, Benjamin Pereira-Zimmermann, Arne Potreck, Dominik F. Vollherbst, Markus A. Möhlenbruch, Christoph Gumbinger, Martin Bendszus, Christian Herweh, Fatih Seker
• Jahr: 2022
• Umfang: 5 S.
• Fussnoten: Online Veröffentlicht: 9 Dezember 2021 ; Gesehen am 28.08.2023
• Titel Quelle: Enthalten in: Neuroradiology
• Ort Quelle: Berlin : Springer, 1970
• Jahr Quelle: 2022
• Band/Heft Quelle: 64(2022), 6, Seite 1195-1199
• ISSN Quelle: 1432-1920
• DOI: doi:10.1007/s00234-021-02873-x
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1858116309
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Purpose  Diabetes is associated with vascular dysfunction potentially impairing collateral recruitment in acute ischemic stroke. This retrospective study aimed at analyzing the impact of diabetes on collateralization assessed on dynamic CTA. - Methods  Collaterals were retrospectively assessed on CT perfusion-derived dynamic CTA according to the mCTA score by Menon in a cohort of patients with an acute occlusion of the M1 segment or carotid T. The extent of collateral circulation was related to the history of diabetes and to admission blood glucose and HbA1c levels. - Results  Two hundred thirty-nine patients were included. The mCTA collateral score was similar in patients with diabetes (median 3, interquartile range 3-4) and without diabetes (median 4, interquartile range 3-4) (P = 0.823). Diabetes was similarly frequent in patients with good (18.8%), intermediate (16.1%), and poor collaterals (16.0%) (P = 0.355). HbA1c was non-significantly higher in patients with poor collaterals (6.3 ± 1.5) compared to patients with intermediate (6.0 ± 0.9) and good collaterals (5.8 ± 0.9) (P = 0.061). Blood glucose levels were significantly higher in patients with poor compared to good collaterals (mean 141.6 vs. 121.8 mg/dl, P = 0.045). However, there was no significant difference between good and intermediate collaterals (mean 121.8 vs. 129.5 mg/dl, P = 0.161) as well as between intermediate and poor collaterals (129.5 vs. 141.6 mg/dl, P = 0.161). - Conclusion  There was no statistically significant difference among patients with good, intermediate, and poor collaterals regarding the presence of diabetes or HbA1c level on admission. However, stroke patients with poor collaterals tend to have higher blood glucose and HbA1c levels.