Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Stremmel, Wolfgang [VerfasserIn]   i
 Hanemann, Anja [VerfasserIn]   i
 Ehehalt, Robert [VerfasserIn]   i
 Karner, Max [VerfasserIn]   i
 Gauss, Annika [VerfasserIn]   i
Titel:Phosphatidylcholine (lecithin) and the mucus layer: evidence of therapeutic efficacy in ulcerative colitis?
Verf.angabe:Wolfgang Stremmel, Anja Hanemann, Robert Ehehalt, Max Karner, Annika Braun
E-Jahr:2010
Jahr:September 30 2010
Umfang:7 S.
Fussnoten:Gesehen am 01.09.2023
Titel Quelle:Enthalten in: Digestive diseases
Ort Quelle:Basel : Karger, 1983
Jahr Quelle:2010
Band/Heft Quelle:28(2010), 3 vom: Okt., Seite 490-496
ISSN Quelle:1421-9875
Abstract:Colonic mucus protects against attacks from bacteria in stool. One component of mucus is phosphatidylcholine (PC) which is thought to be arranged as continuous lamellar layer in the apical mucus and to be responsible for establishing a protective hydrophobic surface. This ‘intestinal surfactant’ plays a key role in mucosal defense. Thus, a defective PC layer contributes to the development of inflammation. Analysis of rectoscopically acquired mucus aliquots revealed a 70% decrease in PC content in ulcerative colitis (UC) compared to Crohn´s disease (CD) and healthy controls - independent of disease activity. Accordingly, we propose that lack of mucus PC is a key pathogenetic factor in UC. In clinical studies a delayed-release oral PC preparation (rPC) was found to substitute the lack of PC in rectal mucus. Indeed, in non-steroid-treated active UC, 53% of rPC patients reached remission [clinical activity index (CAI) ≤3] compared to 10% of placebo patients (p ≤ 0.001). Endoscopic and histologic findings improved concomitantly. A second trial with 60 chronic-active, steroid-dependent UC patients was conducted to test for steroid-sparing effects. Complete steroid withdrawal with a concomitant achievement of remission (CAI ≤3) or clinical response (≧50% CAI improvement) was reached in 15 PC-treated patients (50%) but only in 3 (10%) placebo patients (p = 0.002). In conclusion, intrinsic reduction of PC (lecithin) in colonic mucus may be a key pathogenetic feature of UC. Topical supplement of PC by a delayed-released oral PC preparation is effective in resolving inflammatory activity of UC and may develop to a first-choice therapy for this disease.
DOI:doi:10.1159/000320407
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1159/000320407
 DOI: https://doi.org/10.1159/000320407
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1858515742
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69117977   QR-Code
zum Seitenanfang