The degree of cycle irregularity correlates with the grade of endocrine and metabolic disorders in PCOS patients

• Verfasst von: Strowitzki, Thomas [VerfasserIn]
• Verfasst von: Capp, Edison [VerfasserIn]
• Verfasst von: Corleta, Helena von Eye [VerfasserIn]
• Titel: The degree of cycle irregularity correlates with the grade of endocrine and metabolic disorders in PCOS patients
• Verf.angabe: Thomas Strowitzki, Edison Capp, Helena von Eye Corleta
• E-Jahr: 2010
• Jahr: 25 January 2010
• Umfang: 4 S.
• Fussnoten: Gesehen am 01.09.2023
• Titel Quelle: Enthalten in: European journal of obstetrics & gynecology and reproductive biology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1971
• Jahr Quelle: 2010
• Band/Heft Quelle: 149(2010), 2 vom: Apr., Seite 178-181
• ISSN Quelle: 1872-7654
• DOI: doi:10.1016/j.ejogrb.2009.12.024
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: FSH
• Sach-SW: LH
• Sach-SW: Menstrual cycle
• Sach-SW: PCOS
• Sach-SW: Polycystic ovarian syndrome
• K10plus-PPN: 1858527236

Abstract

Objective - PCOS (polycystic ovarian syndrome) is a clinically heterogeneous endocrine disorder which affects up to 4-10% of women of reproductive age. A standardized definition is still difficult because of a huge variety of different phenotypes. The aim of this study was to evaluate possible correlations between the degree of cycle irregularity and the grade of endocrine and metabolic abnormalities. - Study design - A cross-sectional study was carried out. Hyperandrogenic and/or hirsute women with regular menstrual cycles and polycystic ovaries on ultrasound (PCOS eumenorr, n=45), PCOS patients with oligomenorrhea (PCOS oligo, n=42) and PCOS patients with amenorrhea (PCOS amenorr, n=31) were recruited from the Department of Gynecological Endocrinology and Reproductive Medicine of the Women's University Hospital Heidelberg (Heidelberg, Germany). - Results - Normocyclic patients demonstrated significantly better metabolic parameters (BMI, fasting insulin, HOMA-IR) than patients with oligo/amenorrhea. Hormonal parameters (LH, FSH, FAI and testosterone) were significantly different between patients with different menstrual patterns and patients with regular cycles. - Conclusion - Determining the degree of cycle irregularity as a simple clinical parameter might be a valuable instrument to estimate the degree of metabolic and endocrine disorders. Emphasis should be given to those parameters as a first step to characterize PCOS patients with a risk of endocrine and metabolic disorders leading to consequent detailed examination.