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| Verfasst von: | Schmid, Dominic [VerfasserIn]  |
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| | Warnken, Uwe [VerfasserIn] |
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| | Latzer, Pauline [VerfasserIn] |
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| | Hoffmann, Dirk C. [VerfasserIn] |
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| | Roth, Judith [VerfasserIn] |
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| | Kutschmann, Stefanie [VerfasserIn] |
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| | Jaschonek, Hannah [VerfasserIn] |
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| | Rübmann, Petra [VerfasserIn] |
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| | Foltyn-Dumitru, Martha [VerfasserIn] |
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| | Vollmuth, Philipp [VerfasserIn] |
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| | Winkler, Frank [VerfasserIn] |
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| | Seliger, Corinna [VerfasserIn] |
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| | Felix, Marius [VerfasserIn] |
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| | Sahm, Felix [VerfasserIn] |
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| | Haas, Jürgen [VerfasserIn] |
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| | Reuss, David [VerfasserIn] |
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| | Bendszus, Martin [VerfasserIn] |
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| | Wildemann, Brigitte [VerfasserIn] |
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| | Deimling, Andreas von [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Keßler, Tobias [VerfasserIn] |
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| Titel: | Diagnostic biomarkers from proteomic characterization of cerebrospinal fluid in patients with brain malignancies |
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| Verf.angabe: | Dominic Schmid, Uwe Warnken, Pauline Latzer, Dirk C. Hoffmann, Judith Roth, Stefanie Kutschmann, Hannah Jaschonek, Petra Rübmann, Martha Foltyn, Philipp Vollmuth, Frank Winkler, Corinna Seliger, Marius Felix, Felix Sahm, Jürgen Haas, David Reuss, Martin Bendszus, Brigitte Wildemann, Andreas von Deimling, Wolfgang Wick, Tobias Kessler |
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| Jahr: | 2021 |
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| Umfang: | 17 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 04.09.2023 |
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| Titel Quelle: | Enthalten in: Journal of neurochemistry |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1956 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 158(2021), 2, Seite 522-538 |
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| ISSN Quelle: | 1471-4159 |
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| Abstract: | Recent technological advances in molecular diagnostics through liquid biopsies hold the promise to repetitively monitor tumor evolution and treatment response of brain malignancies without the need of invasive surgical tissue accrual. Here, we implemented a mass spectrometry-based protein analysis pipeline which identified hundreds of proteins in 251 cerebrospinal fluid (CSF) samples from patients with four types of brain malignancies (glioblastoma, lymphoma, brain metastasis, and leptomeningeal disease [LMD]) and from healthy individuals with a focus on glioblastoma in a retrospective and confirmatory prospective observational study. CSF proteome deregulation via disruption of the blood brain barrier appeared to be largely conserved across brain tumor entities. CSF analysis of glioblastoma patients identified two proteomic clusters that correlated with tumor size and patient survival. By integrating CSF data with proteomic analyses of matching glioblastoma tumor tissue and primary glioblastoma cells, we identified potential CSF biomarkers for glioblastoma, in particular chitinase-3-like protein 1 (CHI3L1) and glial fibrillary acidic protein (GFAP). Key findings were validated in a prospective cohort consisting of 35 glioma patients. Finally, in LMD patients who frequently undergo repeated CSF work-up, we explored our proteomic pipeline as a mean to profile consecutive CSF samples. Therefore, proteomic analysis of CSF in brain malignancies has the potential to reveal biomarkers for diagnosis and therapy monitoring. |
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| DOI: | doi:10.1111/jnc.15350 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1111/jnc.15350 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.15350 |
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| | DOI: https://doi.org/10.1111/jnc.15350 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cerebrospinal fluid |
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| | CHI3L1 |
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| | glioblastoma |
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| | proteomic profiling |
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| K10plus-PPN: | 1858747708 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Diagnostic biomarkers from proteomic characterization of cerebrospinal fluid in patients with brain malignancies / Schmid, Dominic [VerfasserIn]; 2021 (Online-Ressource)
