Frauke Melchior: How SUMO wrestles other proteins

• Titel: Frauke Melchior: How SUMO wrestles other proteins
• Mitwirkende: Melchior, Frauke [InterviewteR]
• Mitwirkende: Sedwick, Caitlin [InterviewerIn]
• Verf.angabe: Caitlin Sedwick
• E-Jahr: 2009
• Jahr: November 30, 2009
• Umfang: 2 S.
• Fussnoten: Gesehen am 04.09.2023
• Titel Quelle: Enthalten in: The journal of cell biology
• Ort Quelle: New York, NY : Rockefeller Univ. Press, 1962
• Jahr Quelle: 2009
• Band/Heft Quelle: 187(2009), 5, Seite 586-587
• ISSN Quelle: 1540-8140
• DOI: doi:10.1083/jcb.1875pi
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1858760321

Abstract

Frauke Melchior vividly remembers the afternoon when, as a postdoc in Larry Gerace's laboratory, she developed the film from a particular experiment. It proved that her hypothesis was correct. The mysterious mobility shifts she'd observed in earlier experiments were due to a novel protein modification: addition of the peptide she would name “small ubiquitin-related modifier” (SUMO) (1).Before that day in the darkroom, Melchior had been searching for a research home. Her graduate work in Marburg, Germany with Helmut Kindl had given her a solid grounding in biochemistry, while a two-year stint as a postdoc with Volker Gerke in Göttingen, Germany had opened doors to molecular cell biology and gotten her interested in nuclear-cytoplasmic transport (2). This interest took her to Gerace's laboratory at the Scripps Research Institute in San Diego, CA, where she helped identify the GTPase Ran as a critical player in nuclear transport (3). It was in the course of these studies that she discovered SUMOylation.