Biomechanische Analyse von tomografisch unauffälligen Keratokonus-Partneraugen mit dem Corvis ST

• Verfasst von: Augustin, Victor A. [VerfasserIn]
• Verfasst von: Son, Hyeck Soo [VerfasserIn]
• Verfasst von: Kovalchuk, Bogdana [VerfasserIn]
• Verfasst von: Yildirim, Timur Mert [VerfasserIn]
• Verfasst von: Köppe, Maximilian [VerfasserIn]
• Verfasst von: Auffarth, Gerd U. [VerfasserIn]
• Verfasst von: Khoramnia, Ramin [VerfasserIn]
• Titel: Biomechanische Analyse von tomografisch unauffälligen Keratokonus-Partneraugen mit dem Corvis ST
• Paralleltitel: Biomechanical analysis of tomographically regular keratoconus fellow eyes using Corvis ST
• Verf.angabe: Victor A. Augustin, Hyeck-Soo Son, Bogdana Kovalchuk, Timur Mert Yildirim, Maximilian K. Köppe, Gerd U. Auffarth, Ramin Khoramnia
• Jahr: 2023
• Umfang: 8 S.
• Fussnoten: Artikel online veröffentlicht: 11. August 2023 ; Gesehen am 08.09.2023
• Schrift/Sprache: Sprache der Zusammenfassungen: Deutsch und Englisch
• Titel Quelle: Enthalten in: Klinische Monatsblätter für Augenheilkunde
• Ort Quelle: Stuttgart : Thieme, 1980
• Jahr Quelle: 2023
• Band/Heft Quelle: 240(2023), 8, Seite 944-951
• ISSN Quelle: 1439-3999
• DOI: doi:10.1055/a-2130-7503
• Datenträger: Online-Ressource
• Sprache: ger
• Sach-SW: biomechanical phenomena
• Sach-SW: cornea
• Sach-SW: corneal pachymetry
• Sach-SW: corneal topography
• Sach-SW: dilatation, pathologic
• Sach-SW: elasticity
• Sach-SW: humans
• Sach-SW: keratoconus
• Sach-SW: retrospective studies
• Sach-SW: ROC curve
• K10plus-PPN: 1859145191

Abstract

BACKGROUND: Keratoconus is a bilateral, yet asymmetric disease. In rare cases, the second eye may show no signs of tomographic changes. The purpose of this study was to analyze the biomechanical characteristics in tomographically regular keratoconus fellow eyes. MATERIALS AND METHODS: This retrospective, consecutive case series analyzed 916 eyes of 458 patients who presented to our keratoconus clinic between November 2020 and October 2022. Primary outcome measures included best-corrected visual acuity (BCVA), tomographic Scheimpflug analysis using Pentacam AXL (Oculus, Wetzlar, Germany), and biomechanical assessment using Corvis ST (Oculus, Wetzlar, Germany). Tomographic changes were assessed via analysis of the anterior and posterior curvature, K-max, thinnest corneal thickness (TCT), the Belin/Ambrosio Deviation Display (BAD-D), and the ABCD-Grading. Biomechanical changes were analyzed using Corvis Biomechanical Index (CBI) and Tomographic Biomechanical Index (TBI). RESULTS: Of 916 eyes, 34 tomographically regular fellow eyes (7.4%) were identified and included in the analysis. Overall, the mean BCVA was - 0.02 ± 0.13 logMAR. Tomographic analysis showed mean K-max of 43.87 ± 1.21 D, mean TCT of 532 ± 23 µm, and mean BAD-D of 1.02 ± 0.43. Biomechanical analysis demonstrated mean CBI of 0.28 ± 0.26 and mean TBI of 0.34 ± 0.30. While normal CBI-values were observed in 16 (47%) of 34 eyes, only 13 eyes (38%) showed a regular TBI and only 7 eyes (21%) showed regular TBI and CBI. The sensitivity of CBI and TBI to detect a tomographically normal keratoconus fellow eye was 53% and 62%, respectively. CONCLUSION: A highly asymmetric corneal ectasia with regular tomographic finding in a fellow eye is rare among keratoconus patients. In such cases, a biomechanical analysis may be useful in detecting early signs of corneal ectasia. In our analysis, the TBI showed high sensitivity for detecting a biomechanical abnormality in tomographically regular fellow eyes.