| |  Online-Ressource |
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| Verfasst von: | Vogler, Christine [VerfasserIn]  |
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| | Huber, Claudia [VerfasserIn] |
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| | Waldmann, Tanja [VerfasserIn] |
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| | Ettig, Ramona [VerfasserIn] |
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| | Braun, Lora [VerfasserIn] |
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| | Izzo, Annalisa [VerfasserIn] |
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| | Daujat, Sylvain [VerfasserIn] |
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| | Chassignet, Isabelle [VerfasserIn] |
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| | Lopez-Contreras, Andres Joaquin [VerfasserIn] |
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| | Fernandez-Capetillo, Oscar [VerfasserIn] |
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| | Dundr, Miroslav [VerfasserIn] |
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| | Rippe, Karsten [VerfasserIn] |
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| | Längst, Gernot [VerfasserIn] |
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| | Schneider, Robert [VerfasserIn] |
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| Titel: | Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 Binding |
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| Verf.angabe: | Christine Vogler, Claudia Huber, Tanja Waldmann, Ramona Ettig, Lora Braun, Annalisa Izzo, Sylvain Daujat, Isabelle Chassignet, Andres Joaquin Lopez-Contreras, Oscar Fernandez-Capetillo, Miroslav Dundr, Karsten Rippe, Gernot Längst, Robert Schneider |
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| E-Jahr: | 2010 |
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| Jahr: | December 9, 2010 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 12.09.2023 |
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| Titel Quelle: | Enthalten in: Public Library of SciencePLoS Genetics |
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| Ort Quelle: | San Francisco, Calif. : Public Library of Science, 2005 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 6(2010), 12 vom: Dez., Artikel-ID e1001234, Seite 1-12 |
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| ISSN Quelle: | 1553-7404 |
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| Abstract: | The tails of histone proteins are central players for all chromatin-mediated processes. Whereas the N-terminal histone tails have been studied extensively, little is known about the function of the H2A C-terminus. Here, we show that the H2A C-terminal tail plays a pivotal role in regulating chromatin structure and dynamics. We find that cells expressing C-terminally truncated H2A show increased stress sensitivity. Moreover, both the complete and the partial deletion of the tail result in increased histone exchange kinetics and nucleosome mobility in vivo and in vitro. Importantly, our experiments reveal that the H2A C-terminus is required for efficient nucleosome translocation by ISWI-type chromatin remodelers and acts as a novel recognition module for linker histone H1. Thus, we suggest that the H2A C-terminal tail has a bipartite function: stabilisation of the nucleosomal core particle, as well as mediation of the protein interactions that control chromatin dynamics and conformation. |
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| DOI: | doi:10.1371/journal.pgen.1001234 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1371/journal.pgen.1001234 |
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| | kostenfrei: Volltext: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1001234 |
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| | DOI: https://doi.org/10.1371/journal.pgen.1001234 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biochemical simulations |
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| | Cell fusion |
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| | Chromatin |
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| | DNA-binding proteins |
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| | Ethidium bromide staining |
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| | Histones |
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| | Molecular dynamics |
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| | Nucleosomes |
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| K10plus-PPN: | 1859278221 |
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| Verknüpfungen: | → Zeitschrift |
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Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 Binding / Vogler, Christine [VerfasserIn]; December 9, 2010 (Online-Ressource)
