Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Tambuwala, Murtaza M. [VerfasserIn]   i
 Cummins, Eoin P. [VerfasserIn]   i
 Lenihan, Colin R. [VerfasserIn]   i
 Kiss, Judit [VerfasserIn]   i
 Stauch, Markus [VerfasserIn]   i
 Scholz, Carsten C. [VerfasserIn]   i
 Fraisl, Peter [VerfasserIn]   i
 Lasitschka, Felix [VerfasserIn]   i
 Mollenhauer, Martin [VerfasserIn]   i
 Saunders, Sean P. [VerfasserIn]   i
 Maxwell, Patrick H. [VerfasserIn]   i
 Carmeliet, Peter [VerfasserIn]   i
 Fallon, Padraic G. [VerfasserIn]   i
 Schneider, Martin [VerfasserIn]   i
 Taylor, Cormac T. [VerfasserIn]   i
Titel:Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
Verf.angabe:Murtaza M. Tambuwala, Eoin P. Cummins, Colin R. Lenihan, Judit Kiss, Markus Stauch, Carsten C. Scholz, Peter Fraisl, Felix Lasitschka, Martin Mollenhauer, Sean P. Saunders, Patrick H. Maxwell, Peter Carmeliet, Padraic G. Fallon, Martin Schneider, and Cormac T. Taylor
E-Jahr:2010
Jahr:30 June 2010
Umfang:9 S.
Fussnoten:Gesehen am 15.09.2023
Titel Quelle:Enthalten in: Gastroenterology
Ort Quelle:New York, NY : Elsevier, 1949
Jahr Quelle:2010
Band/Heft Quelle:139(2010), 6, Seite 2093-2101
ISSN Quelle:1528-0012
Abstract:Background & Aims - Hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors are protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the therapeutic target(s) and mechanism(s) involved. - Methods - The effect of genetic deletion of individual HIF-prolyl hydroxylase (PHD) enzymes on the development of dextran sulphate sodium (DSS)-induced colitis was examined in mice. - Results - PHD1−/−, but not PHD2+/− or PHD3−/−, mice were less susceptible to the development of colitis than wild-type controls as determined by weight loss, disease activity, colon histology, neutrophil infiltration, and cytokine expression. Reduced susceptibility of PHD1−/− mice to colitis was associated with increased density of colonic epithelial cells relative to wild-type controls, which was because of decreased levels of apoptosis that resulted in enhanced epithelial barrier function. Furthermore, with the use of cultured epithelial cells it was confirmed that hydroxylase inhibition reversed DSS-induced apoptosis and barrier dysfunction. Finally, PHD1 levels were increased with disease severity in intestinal tissue from patients with IBD and in colonic tissues from DSS-treated mice. - Conclusions - These results imply a role for PHD1 as a positive regulator of intestinal epithelial cell apoptosis in the inflamed colon. Genetic loss of PHD1 is protective against colitis through decreased epithelial cell apoptosis and consequent enhancement of intestinal epithelial barrier function. Thus, targeted PHD1 inhibition may represent a new therapeutic approach in IBD.
DOI:doi:10.1053/j.gastro.2010.06.068
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1053/j.gastro.2010.06.068
 Volltext: https://www.sciencedirect.com/science/article/pii/S0016508510010115
 DOI: https://doi.org/10.1053/j.gastro.2010.06.068
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Apoptosis
 Colitis
 Hydroxylase
 Hypoxia
K10plus-PPN:1859576303
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69122028   QR-Code
zum Seitenanfang