| |  Online-Ressource |
|---|
| Verfasst von: | Otto, Matthias [VerfasserIn]  |
|---|
| | Kropp, Yannik [VerfasserIn] |
|---|
| | Jäger, Evelyn [VerfasserIn] |
|---|
| | Neumaier, Michael [VerfasserIn] |
|---|
| | Thiel, Manfred [VerfasserIn] |
|---|
| | Quintel, Michael [VerfasserIn] |
|---|
| | Tsagogiorgas, Charalambos [VerfasserIn] |
|---|
| Titel: | The use of an inspiration-synchronized vibrating mesh nebulizer for prolonged inhalative iloprost administration in mechanically ventilated patients |
|---|
| Titelzusatz: | an in vitro model |
|---|
| Verf.angabe: | Matthias Otto, Yannik Kropp, Evelyn Jäger, Michael Neumaier, Manfred Thiel, Michael Quintel and Charalambos Tsagogiorgas |
|---|
| E-Jahr: | 2023 |
|---|
| Jahr: | 3 August 2023 |
|---|
| Umfang: | 13 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Gesehen am 19.12.2023 |
|---|
| Titel Quelle: | Enthalten in: Pharmaceutics |
|---|
| Ort Quelle: | Basel : MDPI, 2009 |
|---|
| Jahr Quelle: | 2023 |
|---|
| Band/Heft Quelle: | 15(2023), 8, Artikel-ID 2080, Seite 1-13 |
|---|
| ISSN Quelle: | 1999-4923 |
|---|
| Abstract: | Mechanically ventilated patients suffering from acute respiratory distress syndrome (ARDS) frequently receive aerosolized iloprost. Because of prostacyclin’s short half-life, prolonged inhalative administration might improve its clinical efficacy. But, this is technically challenging. A solution might be the use of inspiration-synchronized vibrating mesh nebulizers (VMNsyn), which achieve high drug deposition rates while showing prolonged nebulization times. However, there are no data comparing prolonged to bolus iloprost nebulization using a continuous vibrating mesh nebulizer (VMNcont) and investigating the effects of different ventilation modes on inspiration-synchronized nebulization. Therefore, in an in vitro model of mechanically ventilated adults, a VMNsyn and a VMNcont were compared in volume-controlled (VC-CMV) and pressure-controlled continuous mandatory ventilation (PC-CMV) regarding iloprost deposition rate and nebulization time. During VC-CMV, the deposition rate of the VMNsyn was comparable to the rate obtained with the VMNcont, but 10.9% lower during PC-CMV. The aerosol output of the VMNsyn during both ventilation modes was significantly lower compared to the VMNcont, leading to a 7.5 times longer nebulization time during VC-CMV and only to a 4.2 times longer nebulization time during PC-CMV. Inspiration-synchronized nebulization during VC-CMV mode therefore seems to be the most suitable for prolonged inhalative iloprost administration in mechanically ventilated patients. |
|---|
| DOI: | doi:10.3390/pharmaceutics15082080 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/pharmaceutics15082080 |
|---|
| | kostenfrei: Volltext: https://www.mdpi.com/1999-4923/15/8/2080 |
|---|
| | DOI: https://doi.org/10.3390/pharmaceutics15082080 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | aerosol deposition |
|---|
| | aerosol drug therapy |
|---|
| | iloprost |
|---|
| | in vitro |
|---|
| | mechanical ventilation |
|---|
| | nebulizers |
|---|
| | vibrating mesh nebulizer |
|---|
| K10plus-PPN: | 1859874355 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
¬The¬ use of an inspiration-synchronized vibrating mesh nebulizer for prolonged inhalative iloprost administration in mechanically ventilated patients / Otto, Matthias [VerfasserIn]; 3 August 2023 (Online-Ressource)
