| |  Online-Ressource |
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| Verfasst von: | Réthelyi, János M. [VerfasserIn]  |
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| | Vincze, Katalin [VerfasserIn] |
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| | Schall, Dorothea [VerfasserIn] |
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| | Glennon, Jeffrey [VerfasserIn] |
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| | Berkel, Simone [VerfasserIn] |
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| Titel: | The role of insulin/IGF1 signalling in neurodevelopmental and neuropsychiatric disorders |
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| Titelzusatz: | evidence from human neuronal cell models |
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| Verf.angabe: | János M. Réthelyi, Katalin Vincze, Dorothea Schall, Jeffrey Glennon, Simone Berkel |
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| E-Jahr: | 2023 |
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| Jahr: | October 2023 |
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| Umfang: | 16 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 27. Juli 2023 ; Gesehen am 21.09.2023 |
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| Titel Quelle: | Enthalten in: Neuroscience & biobehavioral reviews |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1978 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 153(2023) vom: Okt., Artikel-ID 105330, Seite 1-16 |
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| ISSN Quelle: | 1873-7528 |
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| Abstract: | Insulin and insulin-like growth factor 1 (IGF1) signalling play a central role in the development and maintenance of neurons in the brain, and human neurodevelopmental as well as neuropsychiatric disorders have been linked to impaired insulin and IGF1 signalling. This review focuses on the impairments of the insulin and IGF1 signalling cascade in the context of neurodevelopmental and neuropsychiatric disorders, based on evidence from human neuronal cell models. Clear evidence was obtained for impaired insulin and IGF1 receptor downstream signalling in neurodevelopmental disorders, while the evidence for its role in neuropsychiatric disorders was less substantial. Human neuronal model systems can greatly add to our knowledge about insulin/IGF1 signalling in the brain, its role in restoring dendritic maturity, and complement results from clinical studies and animal models. Moreover, they represent a useful model for the development of new therapeutic strategies. Further research is needed to systematically investigate the exact role of the insulin/IGF1 signalling cascades in neurodevelopmental and neuropsychiatric disorders, and to elucidate the respective therapeutic implications. |
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| DOI: | doi:10.1016/j.neubiorev.2023.105330 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neubiorev.2023.105330 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0149763423002993 |
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| | DOI: https://doi.org/10.1016/j.neubiorev.2023.105330 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | AKT |
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| | Disease modelling |
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| | Embryonic stem cells |
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| | IGF1 |
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| | Induced pluripotent stem cells |
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| | Insulin |
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| | MAPK-ERK |
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| | MTOR |
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| | Neurodevelopmental disorders |
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| | Neuronal cell models |
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| | Neuropsychiatric disorders |
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| | RAS |
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| K10plus-PPN: | 186012934X |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ role of insulin/IGF1 signalling in neurodevelopmental and neuropsychiatric disorders / Réthelyi, János M. [VerfasserIn]; October 2023 (Online-Ressource)
