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Status: Bibliographieeintrag

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Verfasst von:Dieterle, Martin P. [VerfasserIn]   i
 Husari, Ayman [VerfasserIn]   i
 Prozmann, Sophie Nicole [VerfasserIn]   i
 Wiethoff, Hendrik [VerfasserIn]   i
 Stenzinger, Albrecht [VerfasserIn]   i
 Röhrich, Manuel [VerfasserIn]   i
 Pfeiffer, Uwe [VerfasserIn]   i
 Kießling, Wolfgang Rüdiger [VerfasserIn]   i
 Engel, Helena [VerfasserIn]   i
 Sourij, Harald [VerfasserIn]   i
 Steinberg, Thorsten [VerfasserIn]   i
 Tomakidi, Pascal [VerfasserIn]   i
 Kopf, Stefan [VerfasserIn]   i
 Szendrödi, Julia [VerfasserIn]   i
Titel:Diffuse, adult-onset nesidioblastosis/non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS)
Titelzusatz:review of the literature of a rare cause of hyperinsulinemic hypoglycemia
Verf.angabe:Martin Philipp Dieterle, Ayman Husari, Sophie Nicole Prozmann, Hendrik Wiethoff, Albrecht Stenzinger, Manuel Röhrich, Uwe Pfeiffer, Wolfgang Rüdiger Kießling, Helena Engel, Harald Sourij, Thorsten Steinberg, Pascal Tomakidi, Stefan Kopf and Julia Szendroedi
E-Jahr:2023
Jahr:16 June 2023
Umfang:42 S.
Fussnoten:Gesehen am 21.09.2023
Titel Quelle:Enthalten in: Biomedicines
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2023
Band/Heft Quelle:11(2023), 6, Artikel-ID 1732, Seite 1-42
ISSN Quelle:2227-9059
Abstract:Differential diagnosis of hypoglycemia in the non-diabetic adult patient is complex and comprises various diseases, including endogenous hyperinsulinism caused by functional β-cell disorders. The latter is also designated as nesidioblastosis or non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS). Clinically, this rare disease presents with unspecific adrenergic and neuroglycopenic symptoms and is, therefore, often overlooked. A combination of careful clinical assessment, oral glucose tolerance testing, 72 h fasting, sectional and functional imaging, and invasive insulin measurements can lead to the correct diagnosis. Due to a lack of a pathophysiological understanding of the condition, conservative treatment options are limited and mostly ineffective. Therefore, nearly all patients currently undergo surgical resection of parts or the entire pancreas. Consequently, apart from faster diagnosis, more elaborate and less invasive treatment options are needed to relieve the patients from the dangerous and devastating symptoms. Based on a case of a 23-year-old man presenting with this disease in our department, we performed an extensive review of the medical literature dealing with this condition and herein presented a comprehensive discussion of this interesting disease, including all aspects from epidemiology to therapy.
DOI:doi:10.3390/biomedicines11061732
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/biomedicines11061732
 Volltext: https://www.mdpi.com/2227-9059/11/6/1732
 DOI: https://doi.org/10.3390/biomedicines11061732
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:congenital hyperinsulinism
 hyperinsulinemic hypoglycemia
 hyperinsulinism
 hyperplasia
 hypoglycemia
 insulinoma
 nesidioblastosis
 pancreatectomy
 positron-emission tomography
K10plus-PPN:1860139361
Verknüpfungen:→ Zeitschrift

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