Peer-induced cocaine seeking in rats

• Verfasst von: Hammerslag, Lindsey R. [VerfasserIn]
• Verfasst von: Humburg, Bree A. [VerfasserIn]
• Verfasst von: Malone, Samantha G. [VerfasserIn]
• Verfasst von: Beckmann, Joshua S. [VerfasserIn]
• Verfasst von: Saatman, Kathryn E. [VerfasserIn]
• Verfasst von: Grinevich, Valéry [VerfasserIn]
• Verfasst von: Bardo, Michael T. [VerfasserIn]
• Titel: Peer-induced cocaine seeking in rats
• Titelzusatz: comparison to nonsocial stimuli and role of paraventricular hypothalamic oxytocin neurons
• Verf.angabe: Lindsey R. Hammerslag, Bree A. Humburg, Samantha G. Malone, Joshua S. Beckmann, Kathryn E. Saatman, Valery Grinevich, Michael T. Bardo
• E-Jahr: 2022
• Jahr: 09 August 2022
• Umfang: 12 S.
• Fussnoten: Gesehen am 25.09.2023
• Titel Quelle: Enthalten in: Addiction biology
• Ort Quelle: Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996
• Jahr Quelle: 2022
• Band/Heft Quelle: 27(2022), 5 vom: Sept., Artikel-ID e13217, Seite 1-12
• ISSN Quelle: 1369-1600
• DOI: doi:10.1111/adb.13217
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cocaine
• Sach-SW: oxytocin
• Sach-SW: self-administration
• Sach-SW: social peer
• K10plus-PPN: 1860228771

Abstract

The purpose of this study was to determine if social vs nonsocial cues (peer vs light/tone) can serve as discriminative stimuli to reinstate cocaine seeking. In addition, to assess a potential mechanism, an oxytocin (OT) promoter-linked hM3Dq DREADD was infused into the paraventricular nucleus of the hypothalamus to determine whether peer-induced cocaine seeking is decreased by activation of OT neurons. Male rats underwent twice-daily self-administration sessions, once with cocaine in the presence of one peer (S+) and once with saline in the presence of a different peer (S−). Another experiment used similar procedures, except the discriminative stimuli were nonsocial (constant vs flashing light/tone), with one stimulus paired with cocaine (S+) and the other paired with saline (S−). A third experiment injected male and female rats with OTp-hM3Dq DREADD or control virus into PVN and tested them for peer-induced reinstatement of cocaine seeking following clozapine (0.1 mg/kg). Although acquisition of cocaine self-administration was similar in rats trained with either peer or light/tone discriminative stimuli, the latency to first response was reduced by the peer S+, but not by the light/tone S+. In addition, the effect of the conditioned stimulus was overshadowed by the peer S+ but not by the light/tone S+. Clozapine blocked the effect of the peer S+ in rats receiving the OTp-hM3Dq DREADD virus, but not in rats receiving the control virus. These results demonstrate that a social peer can serve as potent trigger for drug seeking and that OT in PVN modulates peer-induced reinstatement of cocaine seeking.