Retinal nerve fibre layer thickness in association with gamma zone width and disc-fovea distance

• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Verfasst von: Yan, Yan Ni [VerfasserIn]
• Verfasst von: Zhang, Qi [VerfasserIn]
• Verfasst von: Zhang, Qing [VerfasserIn]
• Verfasst von: Wei, Wen Bin [VerfasserIn]
• Verfasst von: Jonas, Rahul A. [VerfasserIn]
• Verfasst von: Wang, Ya Xing [VerfasserIn]
• Titel: Retinal nerve fibre layer thickness in association with gamma zone width and disc-fovea distance
• Verf.angabe: Jost B. Jonas, Yan Ni Yan, Qi Zhang, Qing Zhang, Wen Bin Wei, Rahul A. Jonas and Ya Xing Wang
• E-Jahr: 2022
• Jahr: 25 January 2022
• Umfang: 8 S.
• Fussnoten: Gesehen am 25.09.2023
• Titel Quelle: Enthalten in: Acta ophthalmologica
• Ort Quelle: Oxford : Blackwell, 2008
• Jahr Quelle: 2022
• Band/Heft Quelle: 100(2022), 6 vom: Sept., Seite 632-639
• ISSN Quelle: 1755-3768
• DOI: doi:10.1111/aos.15088
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: high myopia
• Sach-SW: myopia
• Sach-SW: optic disc
• Sach-SW: optic disc-fovea distance
• Sach-SW: optic nerve damage
• Sach-SW: optic neuropathy
• Sach-SW: parapapillary gamma zone
• Sach-SW: retinal nerve fibre layer
• K10plus-PPN: 1860240232

Abstract

Purpose Previous studies have shown that the retinal nerve fibre layer (RNFL) thickness as surrogate of the optic nerve decreases with longer axial length. We explored which explanatory parameters might explain that association. Methods Participants of the population-based Beijing Eye Study 2011 without any retinal or optic nerve disease were selected based on a refractive error-based stratified randomization. Results The study included of 632 participants (age: 59.1 ± 7.3 years; axial length: 23.5 ± 1.2 mm; range: 20.88-28.68 mm). Thicker RNFL (mean: 101.0 ± 10.0 μm) was associated (multivariable analysis) with smaller parapapillary gamma zone (defined as Bruch's membrane-free parapapillary region) (standardized regression coefficient beta: −0.13; non-stadardized regression coefficient B: −0.008; 95% confidence interval (CI): −0.014, −0.003; p = 0.005) and shorter disc-fovea distance (beta: −0.15; B: −3.91; 95% CI: −6.60; −1.22; p = 0.004), after adjusting for age (beta: −0.22; B: −030; 95% CI: −0.41, −0.19; p < 0.001), gender (beta: 0.12; B: 2.37; 95% CI 0.77, 3.97; p = 0.004) and larger optic disc area (beta: 0.12; B: 0.12; 95% CI: 2.14; 95% CI: 0.54, 3.73; p = 0.009). RNFL thickness decreased by 8 μm (95% CI: 3, 14) for each mm increase in gamma zone width, and by 3.91 μm (95% CI: 1.22, 6.60) for each mm elongation of the disc-fovea distance. If disc-fovea distance and gamma zone width were replaced by axial length, the latter was correlated with RNFL thickness (beta: −0.37; B: −3.12; 95% CI: −3.88, −2.35; p < 0.001). Longer disc-fovea distance was directly associated with larger gamma zone (beta: 0.50; B: p < 0.001). Conclusions The RNFL thickness decrease with longer axial length is associated with a longer optic disc-fovea distance and larger parapapillary gamma zone. Longer disc-fovea distance and larger gamma zone lead to an elongation and stretching of the retinal nerve fibres, potentially causing a thinning or loss of the nerve fibres. It may explain the occurrence of visual field defects in some non-glaucomatous highly myopic eyes without macular correlates of the perimetric defects.