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| Verfasst von: | Oberle, Raimund [VerfasserIn]  |
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| | Kührer, Kristina [VerfasserIn] |
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| | Österreicher, Tamina [VerfasserIn] |
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| | Weber, Florian [VerfasserIn] |
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| | Steinbauer, Stefanie [VerfasserIn] |
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| | Udonta, Florian [VerfasserIn] |
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| | Wroblewski, Mark [VerfasserIn] |
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| | Ben-Batalla, Isabel [VerfasserIn] |
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| | Hassl, Ingrid [VerfasserIn] |
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| | Körbelin, Jakob [VerfasserIn] |
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| | Unseld, Matthias [VerfasserIn] |
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| | Jauhiainen, Matti [VerfasserIn] |
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| | Plochberger, Birgit [VerfasserIn] |
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| | Röhrl, Clemens [VerfasserIn] |
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| | Hengstschläger, Markus [VerfasserIn] |
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| | Loges, Sonja [VerfasserIn] |
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| | Stangl, Herbert [VerfasserIn] |
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| Titel: | The HDL particle composition determines its antitumor activity in pancreatic cancer |
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| Titelzusatz: | research article |
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| Verf.angabe: | Raimund Oberle, Kristina Kührer, Tamina Österreicher, Florian Weber, Stefanie Steinbauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ingrid Hassl, Jakob Körbelin, Matthias Unseld, Matti Jauhiainen, Birgit Plochberger, Clemens Röhrl, Markus Hengstschläger, Sonja Loges, Herbert Stangl |
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| E-Jahr: | 2022 |
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| Jahr: | 16 May 2022 |
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| Umfang: | 16 S. |
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| Fussnoten: | Gesehen am 02.10.2023 |
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| Titel Quelle: | Enthalten in: Life science alliance |
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| Ort Quelle: | Heidelberg : EMBO Press, 2018 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 5(2022), 9, Artikel-ID e202101317, Seite 1-16 |
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| ISSN Quelle: | 2575-1077 |
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| Abstract: | Despite enormous efforts to improve therapeutic options, pancreatic cancer remains a fatal disease and is expected to become the second leading cause of cancer-related deaths in the next decade. Previous research identified lipid metabolic pathways to be highly enriched in pancreatic ductal adenocarcinoma (PDAC) cells. Thereby, cholesterol uptake and synthesis promotes growth advantage to and chemotherapy resistance for PDAC tumor cells. Here, we demonstrate that high-density lipoprotein (HDL)-mediated efficient cholesterol removal from cancer cells results in PDAC cell growth reduction and induction of apoptosis in vitro. This effect is driven by an HDL particle composition-dependent interaction with SR-B1 and ABCA1 on cancer cells. AAV-mediated overexpression of APOA1 and rHDL injections decreased PDAC tumor development in vivo. Interestingly, plasma samples from pancreatic-cancer patients displayed a significantly reduced APOA1-to-SAA1 ratio and a reduced cholesterol efflux capacity compared with healthy donors. We conclude that efficient, HDL-mediated cholesterol depletion represents an interesting strategy to interfere with the aggressive growth characteristics of PDAC. |
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| DOI: | doi:10.26508/lsa.202101317 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.26508/lsa.202101317 |
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| | kostenfrei: Volltext: https://www.life-science-alliance.org/content/5/9/e202101317 |
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| | DOI: https://doi.org/10.26508/lsa.202101317 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1860612938 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ HDL particle composition determines its antitumor activity in pancreatic cancer / Oberle, Raimund [VerfasserIn]; 16 May 2022 (Online-Ressource)
