A shea butter-based ketamine ointment

• Verfasst von: Akan, Merve [VerfasserIn]
• Verfasst von: Skorodumov, Ivan [VerfasserIn]
• Verfasst von: Meinhardt, Marcus W. [VerfasserIn]
• Verfasst von: Canbeyli, Resit [VerfasserIn]
• Verfasst von: Unal, Gunes [VerfasserIn]
• Titel: A shea butter-based ketamine ointment
• Titelzusatz: the antidepressant effects of transdermal ketamine in rats
• Verf.angabe: Merve Akan, Ivan Skorodumov, Marcus W. Meinhardt, Resit Canbeyli, Gunes Unal
• Jahr: 2023
• Umfang: 5 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar 23 July 2023, Artikelversion 25 July 2023 ; Gesehen am 04.10.2023
• Titel Quelle: Enthalten in: Behavioural brain research
• Ort Quelle: Amsterdam : Elsevier, 1980
• Jahr Quelle: 2023
• Band/Heft Quelle: 452(2023) vom: Aug., Artikel-ID 114594, Seite 1-5
• ISSN Quelle: 1872-7549
• DOI: doi:10.1016/j.bbr.2023.114594
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: behavioral despair
• Sach-SW: depression
• Sach-SW: ketamine
• Sach-SW: ointment
• Sach-SW: shea butter
• Sach-SW: transdermal
• K10plus-PPN: 1860675107

Abstract

The delayed onset of monoaminergic antidepressants and disadvantages of traditional administration routes created the need for alternative non-invasive delivery methods with rapid onset therapeutic effect. Ketamine attracted attention as a fast-acting glutamatergic antidepressant with ideal physiochemical properties for alternative routes of administration. However, there is no sufficient data for its transdermal use in depression. In this proof-of-concept study, we investigated the antidepressant effects of transdermal ketamine delivered via a novel ointment with skin protective, emulsifying and permeation enhancing properties. A shea butter-based 5% (w/w) ketamine ointment or a drug-free vehicle ointment were applied to the shaved dorsal skin of male Wistar rats for 2 days, twice a day. Behavioral despair, locomotor activity and anxiety-like behavior were respectively assessed in the forced swim test (FST), open field test (OFT), and elevated plus maze (EPM). The pharmacokinetic profile of the ointment was analyzed with high-performance liquid chromatography. Transdermal ketamine ameliorated behavioral despair without altering general locomotor activity and anxiety-like behavior, showing that skin-friendly drug carriers like shea butter may constitute promising alternatives to current routes of delivery for ketamine. Tested transdermal method aims to provide more sustainable drug delivery for long-term treatment schedules. Future studies can investigate its long-term use, side effects and abuse liability.