Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Sprynski, A. C. [VerfasserIn]  |
| Hose, Dirk [VerfasserIn]  |
| Kassambara, A. [VerfasserIn]  |
| Vincent, L. [VerfasserIn]  |
| Jourdan, M. [VerfasserIn]  |
| Rossi, J. F. [VerfasserIn]  |
| Goldschmidt, Hartmut [VerfasserIn]  |
| Klein, B. [VerfasserIn]  |
Titel: | Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation |
Verf.angabe: | A.C. Sprynski, D. Hose, A. Kassambara, L. Vincent, M. Jourdan, J.F. Rossi, H. Goldschmidt and B. Klein |
E-Jahr: | 2010 |
Jahr: | 16 September 2010 |
Umfang: | 11 S. |
Fussnoten: | Gesehen am 05.10.2023 |
Titel Quelle: | Enthalten in: Leukemia |
Ort Quelle: | London : Springer Nature, 1997 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 24(2010), 11, Seite 1940-1950 |
ISSN Quelle: | 1476-5551 |
Abstract: | Insulin and insulin growth factor type 1 (IGF-1) and their receptors are closely related molecules, but both factors bind to the receptor of the other one with a weak affinity. No study has presently documented a role of insulin as a myeloma growth factor (MGF) for human multiple myeloma cells (MMCs), whereas many studies have concluded that IGF-1 is a major MGF. IGF-1 receptor (IGF-1R) is aberrantly expressed by MMCs in association with a poor prognosis. In this study we show that insulin receptor (INSR) is increased throughout normal plasma cell differentiation. INSR gene is also expressed by MMCs of 203/206 newly diagnosed patients. Insulin is an MGF as potent as IGF-1 at physiological concentrations and requires the presence of insulin/IGF-1 hybrid receptors, stimulating INSR+IGF-1R+ MMCs, unlike INSR+IGF-1R− or INSR−IGF-1R− MMCs. Immunoprecipitation experiments indicate that INSR is linked with IGF-1R in MMCs and that insulin induces both IGF-1R and INSR phosphorylations and vice versa. In conclusion, we demonstrate for the first time that insulin is an MGF as potent as IGF-1 at physiological concentrations and its activity necessitates insulin/IGF-1 hybrid receptor activation. Further therapeutic strategies targeting the IGF/IGF-1R pathway have to take into account neutralizing the IGF-1R-mediated insulin MGF activity. |
DOI: | doi:10.1038/leu.2010.192 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/leu.2010.192 |
| Volltext: https://www.nature.com/articles/leu2010192 |
| DOI: https://doi.org/10.1038/leu.2010.192 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Insulin signalling |
| Myeloma |
K10plus-PPN: | 1860822584 |
Verknüpfungen: | → Zeitschrift |
Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation / Sprynski, A. C. [VerfasserIn]; 16 September 2010 (Online-Ressource)
69127012