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Verfasst von:Sprynski, A. C. [VerfasserIn]   i
 Hose, Dirk [VerfasserIn]   i
 Kassambara, A. [VerfasserIn]   i
 Vincent, L. [VerfasserIn]   i
 Jourdan, M. [VerfasserIn]   i
 Rossi, J. F. [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Klein, B. [VerfasserIn]   i
Titel:Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation
Verf.angabe:A.C. Sprynski, D. Hose, A. Kassambara, L. Vincent, M. Jourdan, J.F. Rossi, H. Goldschmidt and B. Klein
E-Jahr:2010
Jahr:16 September 2010
Umfang:11 S.
Fussnoten:Gesehen am 05.10.2023
Titel Quelle:Enthalten in: Leukemia
Ort Quelle:London : Springer Nature, 1997
Jahr Quelle:2010
Band/Heft Quelle:24(2010), 11, Seite 1940-1950
ISSN Quelle:1476-5551
Abstract:Insulin and insulin growth factor type 1 (IGF-1) and their receptors are closely related molecules, but both factors bind to the receptor of the other one with a weak affinity. No study has presently documented a role of insulin as a myeloma growth factor (MGF) for human multiple myeloma cells (MMCs), whereas many studies have concluded that IGF-1 is a major MGF. IGF-1 receptor (IGF-1R) is aberrantly expressed by MMCs in association with a poor prognosis. In this study we show that insulin receptor (INSR) is increased throughout normal plasma cell differentiation. INSR gene is also expressed by MMCs of 203/206 newly diagnosed patients. Insulin is an MGF as potent as IGF-1 at physiological concentrations and requires the presence of insulin/IGF-1 hybrid receptors, stimulating INSR+IGF-1R+ MMCs, unlike INSR+IGF-1R− or INSR−IGF-1R− MMCs. Immunoprecipitation experiments indicate that INSR is linked with IGF-1R in MMCs and that insulin induces both IGF-1R and INSR phosphorylations and vice versa. In conclusion, we demonstrate for the first time that insulin is an MGF as potent as IGF-1 at physiological concentrations and its activity necessitates insulin/IGF-1 hybrid receptor activation. Further therapeutic strategies targeting the IGF/IGF-1R pathway have to take into account neutralizing the IGF-1R-mediated insulin MGF activity.
DOI:doi:10.1038/leu.2010.192
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1038/leu.2010.192
 Volltext: https://www.nature.com/articles/leu2010192
 DOI: https://doi.org/10.1038/leu.2010.192
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Insulin signalling
 Myeloma
K10plus-PPN:1860822584
Verknüpfungen:→ Zeitschrift

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