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| Verfasst von: | Garnier, Alice [VerfasserIn]  |
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| | Robin, Marie [VerfasserIn] |
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| | Larosa, Fabrice [VerfasserIn] |
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| | Golmard, Jean-Louis [VerfasserIn] |
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| | Gouill, Steven Le [VerfasserIn] |
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| | Coiteux, Valérie [VerfasserIn] |
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| | Tabrizi, Reza [VerfasserIn] |
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| | Bulabois, Claude-Eric [VerfasserIn] |
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| | Cacheux, Victoria [VerfasserIn] |
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| | Kuentz, Mathieu [VerfasserIn] |
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| | Dreyfus, Brigitte [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| | Rio, Bernard [VerfasserIn] |
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| | Moles-Moreau, Marie-Pierre [VerfasserIn] |
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| | Bilger, Karin [VerfasserIn] |
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| | Bay, Jacques-Olivier [VerfasserIn] |
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| | Leblond, Véronique [VerfasserIn] |
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| | Blaise, Didier [VerfasserIn] |
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| | Tournilhac, Olivier [VerfasserIn] |
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| | Dhédin, Nathalie [VerfasserIn] |
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| Titel: | Allogeneic hematopoietic stem cell transplantation allows long-term complete remission and curability in high-risk Waldenström’s macroglobulinemia |
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| Titelzusatz: | results of a retrospective analysis of the Société Française de Greffe de Moelle et de Thérapie Cellulaire |
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| Verf.angabe: | Alice Garnier, Marie Robin, Fabrice Larosa, Jean-Louis Golmard, Steven Le Gouill, Valérie Coiteux, Reza Tabrizi, Claude-Eric Bulabois, Victoria Cacheux, Mathieu Kuentz, Brigitte Dreyfus, Peter Dreger, Bernard Rio, Marie-Pierre Moles-Moreau, Karin Bilger, Jacques-Olivier Bay, Véronique Leblond, Didier Blaise, Olivier Tournilhac, and Nathalie Dhédin |
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| E-Jahr: | 2010 |
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| Jahr: | June, 2010 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 10.10.2023 |
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| Titel Quelle: | Enthalten in: Haematologica, the hematology journal |
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| Ort Quelle: | Pavia : Ferrata Storti Foundation, 2005 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 95(2010), 6 vom: Juni, Seite 950-955 |
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| ISSN Quelle: | 1592-8721 |
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| Abstract: | Background Patients with poor-risk Waldenström’s macroglobulinemia have suboptimal response and early post-treatment relapse with conventional therapies. Hence, new therapeutic approaches such as allogeneic stem cell transplantation should be evaluated in these patients.Design and Methods We examined the long-term outcome of allogeneic stem cell transplantation in Waldenström’s macroglobulinemia by studying the records of 24 patients reported in the SFGM-TC database and one transplanted in the bone marrow unit in Hamburg.Results Median age at the time of transplant was 48 years (range, 24-64). The patients had previously received a median of 3 lines of therapy (range, 1-6) and 44% of them had refractory disease at time of transplant. Allogeneic stem cell transplantation after myeloablative (n=12) or reduced-intensity (n=13) conditioning yielded an overall response rate of 92% and immunofixation-negative complete remission in 50% of evaluable patients. With a median follow-up of 64 months among survivors (range, 11-149 months), 5-year overall survival and progression-free survival rates were respectively, 67% (95% CI: 46-81) and 58% (95% CI: 38-75). The 5-year estimated risk of progression was 25% (95% CI: 10-36%), with only one relapse among the 12 patients who entered complete remission, versus 5 in the 12 patients who did not. Only one of the 6 relapses occurred more than three years post-transplant.Conclusions Allogeneic stem cell transplantation yields a high rate of complete remissions and is potentially curative in poor-risk Waldenström’s macroglobulinemia. |
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| DOI: | doi:10.3324/haematol.2009.017814 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3324/haematol.2009.017814 |
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| | kostenfrei: Volltext: https://haematologica.org/article/view/5632 |
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| | DOI: https://doi.org/10.3324/haematol.2009.017814 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1861136692 |
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| Verknüpfungen: | → Zeitschrift |
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Allogeneic hematopoietic stem cell transplantation allows long-term complete remission and curability in high-risk Waldenström’s macroglobulinemia / Garnier, Alice [VerfasserIn]; June, 2010 (Online-Ressource)
