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Verfasst von:Kälsch, Anna-Isabelle [VerfasserIn]   i
 Csernok, Elena [VerfasserIn]   i
 Münch, Dominik [VerfasserIn]   i
 Birck, Rainer [VerfasserIn]   i
 Yard, Benito A. [VerfasserIn]   i
 Gross, Wolfgang [VerfasserIn]   i
 Kälsch, Thorsten [VerfasserIn]   i
 Schmitt, Wilhelm [VerfasserIn]   i
Titel:Use of highly sensitive C-reactive protein for followup of Wegener’s granulomatosis
Verf.angabe:Anna-Isabelle Kälsch, Elena Csernok, Dominik Münch, Rainer Birck, Benito A. Yard, Wolfgang Gross, Thorsten Kälsch, and Wilhelm H. Schmitt
E-Jahr:2010
Jahr:[November 2010]
Umfang:7 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 10.10.2023
Titel Quelle:Enthalten in: The journal of rheumatology
Ort Quelle:Toronto, Ont. : [Verlag nicht ermittelbar], 2001
Jahr Quelle:2010
Band/Heft Quelle:37(2010), 11 vom: Nov., Seite 2319-2325
ISSN Quelle:1499-2752
Abstract:Objective. Since Wegener’s granulomatosis (WG) represents a relapsing disease, efforts have been made to reliably predict relapses using blood tests. Followup measures such as conventionally determined C-reactive protein (CRP), antineutrophil cytoplasmic antibody (C-ANCA) titer, and proteinase-3 (PR3) ELISA are applied. We evaluated whether during remission elevated highly sensitive CRP (hsCRP) precedes relapse as a marker of subclinical inflammation and thus might improve clinical assessment. - Methods. We investigated 227 sera of 57 patients with WG: 74 sera collected from patients in remission who subsequently relapsed (before relapse), 30 sera collected during relapse, and 123 sera from patients in remission without relapse. We also distinguished between major and minor relapse. hsCRP, conventionally determined CRP (CRP), C-ANCA, PR3-ELISA, and erythrocyte sedimentation rate (ESR) were measured using commercial kits, and levels were correlated to clinical status. - Results. Only hsCRP and ANCA titer, but not CRP levels, were higher in sera from patients who subsequently relapsed versus those who did not, indicating patients at risk. Levels of hsCRP, CRP, and ESR were higher in sera collected during relapse than in the sera before relapse. hsCRP, conventional CRP, and ESR were also higher in samples collected during major relapse than before major relapse. Looking at the levels just before relapse compared to previous levels during remission, none of these measures rose directly before the clinical manifestation of the relapse. - Conclusion. Our study provides evidence for an additional value of hsCRP in the clinical assessment of patients with WG.
DOI:doi:10.3899/jrheum.100302
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3899/jrheum.100302
 Volltext: https://www.jrheum.org/content/37/11/2319
 DOI: https://doi.org/10.3899/jrheum.100302
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES
 C-REACTIVE PROTEIN
 RELAPSE
 WEGENER’S GRANULOMATOSIS
K10plus-PPN:1861145985
Verknüpfungen:→ Zeitschrift

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