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| Verfasst von: | Gökbuget, Nicola [VerfasserIn]  |
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| | Ihrig, Kristina [VerfasserIn] |
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| | Stadler, Michael [VerfasserIn] |
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| | Stelljes, Matthias [VerfasserIn] |
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| | Elmaaḡaçlı, Ahmet Hayri [VerfasserIn] |
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| | Starck, Michael [VerfasserIn] |
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| | Raffel, Simon [VerfasserIn] |
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| | Stoltefuss, Andrea [VerfasserIn] |
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| | Viardot, Andreas [VerfasserIn] |
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| | Kreuzer, Karl-Anton [VerfasserIn] |
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| | Heidenreich, Daniela [VerfasserIn] |
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| | Renzelmann, Andrea [VerfasserIn] |
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| | Wäsch, Ralph [VerfasserIn] |
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| | Topp, Max S. [VerfasserIn] |
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| | Ritter, Barbara [VerfasserIn] |
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| | Reimer, Peter [VerfasserIn] |
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| | Beck, Joachim [VerfasserIn] |
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| | Westermann, Jörg [VerfasserIn] |
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| | Wendelin, Knut [VerfasserIn] |
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| | Alakel, Nael [VerfasserIn] |
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| | Hanoun, Maher [VerfasserIn] |
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| | Serve, Hubert [VerfasserIn] |
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| | Hoelzer, Dieter [VerfasserIn] |
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| Titel: | General condition and comorbidity of long-term survivors of adult acute lymphoblastic leukemia |
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| Verf.angabe: | Nicola Gökbuget, Kristina Ihrig, Michael Stadler, Matthias Stelljes, Ahmet Elmaagacli, Michael Starck, Simon Raffel, Andrea Stoltefuss, Andreas Viardot, Karl-Anton Kreuzer, Daniela Heidenreich, Andrea Renzelmann, Ralph Wäsch, Max S. Topp, Barbara Ritter, Peter Reimer, Joachim Beck, Jörg Westermann, Knut Wendelin, Nael Alakel, Maher Hanoun, Hubert Serve and Dieter Hoelzer |
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| E-Jahr: | 2023 |
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| Jahr: | July, 2023 |
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| Umfang: | 10 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 11.10.2023 |
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| Titel Quelle: | Enthalten in: Haematologica |
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| Ort Quelle: | Pavia : Ferrata Storti Foundation, 2014 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 108(2023), 7 vom: Juli, Seite 1758-1767 |
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| ISSN Quelle: | 1592-8721 |
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| Abstract: | Cure rates in adult acute lymphoblastic leukemia (ALL) improved using pediatric-based chemotherapy and stem cell transplantation (SCT). However, limited data on the health condition of cured adults are available whereas pediatric data cannot be transferred. The GMALL analyzed the health status in survivors of adult ALL retrospectively. Physicians answered a questionnaire on general condition (Eastern Cooperative Oncology Group [ECOG] status) and comorbidity or syndrome occurrence observed after treatment. Five hundred and thirty-eight patients with a median age of 29 (range, 15-64) years at diagnosis were analyzed, median follow-up was 7 (range, 3-24) years. Thirty-one percent had received SCT. ECOG status was 0-1 in 94%, 34% had not developed significant comorbidities. Most frequent comorbidities involved the neurologic system (27%), endocrine system (20%), skin (18%), graft-versus-host-disease (15%), cardiac system (13%), fatigue (13%). SCT impacted ECOG status and comorbidity occurrence significantly. ECOG 0-1 was observed in 86% of SCT and 98% of non-SCT patients (P<0.0001); comorbidity was observed in 87% and 57% respectively (P<0.0001). Our analysis elucidates the spectrum of comorbidities in cured adult ALL patients, with higher risk for transplanted patients, providing stimulations for the design of adequate aftercare programs. Overall, a large proportion of non-SCT patients achieved unrestricted general condition. The data provide a reference for new patient-centered endpoints in future trials. |
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| DOI: | doi:10.3324/haematol.2022.281820 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3324/haematol.2022.281820 |
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| | Volltext: https://haematologica.org/article/view/haematol.2022.281820 |
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| | DOI: https://doi.org/10.3324/haematol.2022.281820 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1861530803 |
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| Verknüpfungen: | → Zeitschrift |
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General condition and comorbidity of long-term survivors of adult acute lymphoblastic leukemia / Gökbuget, Nicola [VerfasserIn]; July, 2023 (Online-Ressource)
