| Online-Ressource |
Verfasst von: | Brandelik, Simone Christine [VerfasserIn] |
| Skornitzke, Stephan [VerfasserIn] |
| Mokry, Theresa [VerfasserIn] |
| Sauer, Sandra [VerfasserIn] |
| Stiller, Wolfram [VerfasserIn] |
| Nattenmüller, Johanna [VerfasserIn] |
| Kauczor, Hans-Ulrich [VerfasserIn] |
| Weber, Tim [VerfasserIn] |
| Do, Thuy [VerfasserIn] |
Titel: | Quantitative and qualitative assessment of plasma cell dyscrasias in dual-layer spectral CT |
Verf.angabe: | S.C. Brandelik, S. Skornitzke, T. Mokry, S. Sauer, W. Stiller, J. Nattenmüller, H.U. Kauczor, T. F. Weber, T.D. Do |
E-Jahr: | 2021 |
Jahr: | 30 March 2021 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 17.10.2023 |
Titel Quelle: | Enthalten in: European radiology |
Ort Quelle: | Berlin : Springer, 1991 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 31(2021), 10, Seite 7664-7673 |
ISSN Quelle: | 1432-1084 |
| 1613-3757 |
Abstract: | Objectives Virtual non-calcium (VNCa) images could improve assessment of plasma cell dyscrasias by enhancing visibility of bone marrow. Thus, VNCa images from dual-layer spectral CT (DLCT) were evaluated at different calcium suppression (CaSupp) indices, correlating results with apparent diffusion coefficient (ADC) values from MRI. - Methods Thirty-two patients with initial clinical diagnosis of a plasma cell dyscrasia before any chemotherapeutic treatment, who had undergone whole-body low-dose DLCT and MRI within 2 months, were retrospectively enrolled. VNCa images with CaSupp indices ranging from 25 to 95 in steps of 10, conventional CT images, and ADC maps were quantitatively analyzed using region-of-interests in the vertebral bodies C7, T12, L1-L5, and the iliac bone. Independent two-sample t-test, Wilcoxon-signedrank test, Pearson’s correlation, and ROC analysis were performed. - Results Eighteen patients had a non-diffuse, 14 a diffuse infiltration in conventional MRI. A significant difference between diffuse and non-diffuse infiltration was shown for VNCa-CT with CaSupp indices from 55 to 95, for conventional CT, and for ADC (each p < 0.0001). Significant quantitative correlation between VNCa-CT and MRI could be found with strongest correlation at CaSupp index 65 for L3 (r = 0.68, p < 0.0001) and averaged L1-L5 (r = 0.66, p < 0.0001). The optimum CT number cut-off point for differentiation between diffuse and non-diffuse infiltration at CaSupp index 65 for averaged L1-L5 was −1.6 HU (sensitivity 78.6%, specificity 75.0%). - Conclusion Measurements in VNCa-CT showed the highest correlation with ADC at CaSupp index 65. VNCa technique may prove useful for evaluation of bone marrow infiltration if MRI is not feasible. Key Points • VNCa-CT images can support the evaluation of bone marrow infiltration in plasma cell dyscrasias. • VNCa measurements of vertebral bodies show significant correlation with ADC in MRI. • Averaging L1-L5 at CaSupp index 65 allowed quantitative detection of infiltration comparable to MRI ADC. |
DOI: | doi:10.1007/s00330-021-07821-0 |
URL: | kostenfrei: Volltext: https://doi.org/10.1007/s00330-021-07821-0 |
| kostenfrei: Volltext: https://link.springer.com/10.1007/s00330-021-07821-0 |
| DOI: https://doi.org/10.1007/s00330-021-07821-0 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1865943843 |
Verknüpfungen: | → Zeitschrift |
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Lokale URL UB: | Zum Volltext |
Quantitative and qualitative assessment of plasma cell dyscrasias in dual-layer spectral CT / Brandelik, Simone Christine [VerfasserIn]; 30 March 2021 (Online-Ressource)