| |  Online-Ressource |
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| Verfasst von: | Rott, Jeremy [VerfasserIn]  |
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| | Töpfer, Eva Teresa [VerfasserIn] |
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| | Bartosova, Maria [VerfasserIn] |
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| | Damgov, Ivan [VerfasserIn] |
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| | Kolevica, Ana [VerfasserIn] |
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| | Heuser, Alexander [VerfasserIn] |
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| | Shroff, Rukshana [VerfasserIn] |
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| | Zarogiannis, Sotirios G. [VerfasserIn] |
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| | Eisenhauer, Anton [VerfasserIn] |
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| | Schmitt, Claus P. [VerfasserIn] |
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| Titel: | Calcimimetic AMG-416 induced short-term changes in calcium concentrations and calcium isotope ratios in rats |
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| Verf.angabe: | Jeremy Rott, Eva Teresa Töpfer, Maria Bartosova, Ivan Damgov, Ana Kolevica, Alexander Heuser, Rukshana Shroff, Sotirios G. Zarogiannis, Anton Eisenhauer, Claus Peter Schmitt |
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| E-Jahr: | 2023 |
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| Jahr: | 15 October 2023 |
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| Umfang: | 5 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 1. August 2023, Artikelversion: 8. August 2023 ; Gesehen am 18.10.2023 |
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| Titel Quelle: | Enthalten in: Biochemical and biophysical research communications |
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| Ort Quelle: | Orlando, Fla. : Academic Press, 1959 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 677(2023) vom: Okt., Seite 88-92 |
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| ISSN Quelle: | 1090-2104 |
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| Abstract: | Calcium (Ca) isotopes (δ44/42Ca) in serum and urine have been suggested as novel sensitive markers of bone calcification. The response of δ44/42Ca to acute changes in Ca homeostasis, has not yet been demonstrated. We measured serum Ca and δ44/42Ca in rats maintained on a standard and a 50% Ca reduced diet for 4 weeks, and after injection of 1 mg/kg of the calcimimetic AMG-416, 24 h prior to sacrifice. AMG-416 decreased serum Ca by a maximum of 0.38 ± 0.10 and 0.53 ± 0.35 mmol/l after 12 and 6 h, respectively, in the standard and low-Ca diet groups (p = 0.0006/0.02), while serum δ44/42Ca did not change over 24 h in both groups. Urinary Ca concentrations were higher 24 h after AMG-416 injection in both groups (p = 0.03/0.06), urine δ44/42Ca was not different compared to the untreated control groups. Our data does not show acute changes in δ44/42Ca in response to a single dose of AMG-416 within 24 h after injection, possibly due to a lack of bone calcification. |
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| DOI: | doi:10.1016/j.bbrc.2023.07.060 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.bbrc.2023.07.060 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0006291X23009324 |
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| | DOI: https://doi.org/10.1016/j.bbrc.2023.07.060 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Calcimimetic |
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| | Calcium |
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| | Calcium isotopes |
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| | Fractionation |
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| K10plus-PPN: | 1866207830 |
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| Verknüpfungen: | → Zeitschrift |
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Calcimimetic AMG-416 induced short-term changes in calcium concentrations and calcium isotope ratios in rats / Rott, Jeremy [VerfasserIn]; 15 October 2023 (Online-Ressource)
