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| Verfasst von: | Quintana, Juan F. [VerfasserIn]  |
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| | Sinton, Matthew C. [VerfasserIn] |
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| | Chandrasegaran, Praveena [VerfasserIn] |
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| | Lestari, Agatha Nabilla [VerfasserIn] |
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| | Heslop, Rhiannon [VerfasserIn] |
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| | Cheaib, Bachar [VerfasserIn] |
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| | Ogunsola, John [VerfasserIn] |
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| | Ngoyi, Dieudonne Mumba [VerfasserIn] |
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| | Kuispond Swar, Nono-Raymond [VerfasserIn] |
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| | Cooper, Anneli [VerfasserIn] |
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| | Mabbott, Neil A. [VerfasserIn] |
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| | Coffelt, Seth B. [VerfasserIn] |
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| | MacLeod, Annette [VerfasserIn] |
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| Titel: | γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection |
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| Verf.angabe: | Juan F. Quintana, Matthew C. Sinton, Praveena Chandrasegaran, Agatha Nabilla Lestari, Rhiannon Heslop, Bachar Cheaib, John Ogunsola, Dieudonne Mumba Ngoyi, Nono-Raymond Kuispond Swar, Anneli Cooper, Neil A. Mabbott, Seth B. Coffelt & Annette MacLeod |
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| Jahr: | 2023 |
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| Umfang: | 17 S. |
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| Fussnoten: | Veröffentlicht: 29. August 2023 ; Gesehen am 19.10.2023 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 14(2023), Artikel-ID 5279, Seite 1-17 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | African trypanosomes colonise the skin to ensure parasite transmission. However, how the skin responds to trypanosome infection remains unresolved. Here, we investigate the local immune response of the skin in a murine model of infection using spatial and single cell transcriptomics. We detect expansion of dermal IL-17A-producing Vγ6+ cells during infection, which occurs in the subcutaneous adipose tissue. In silico cell-cell communication analysis suggests that subcutaneous interstitial preadipocytes trigger T cell activation via Cd40 and Tnfsf18 signalling, amongst others. In vivo, we observe that female mice deficient for IL-17A-producing Vγ6+ cells show extensive inflammation and limit subcutaneous adipose tissue wasting, independently of parasite burden. Based on these observations, we propose that subcutaneous adipocytes and Vγ6+ cells act in concert to limit skin inflammation and adipose tissue wasting. These studies provide new insights into the role of γδ T cell and subcutaneous adipocytes as homeostatic regulators of skin immunity during chronic infection. |
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| DOI: | doi:10.1038/s41467-023-40962-y |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-023-40962-y |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-023-40962-y |
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| | DOI: https://doi.org/10.1038/s41467-023-40962-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Chronic inflammation |
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| | Infection |
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| | Parasite host response |
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| | Parasitic infection |
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| K10plus-PPN: | 1866382616 |
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| Verknüpfungen: | → Zeitschrift |
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γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection / Quintana, Juan F. [VerfasserIn]; 2023 (Online-Ressource)
