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| Verfasst von: | Giroud, Maude [VerfasserIn]  |
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| | Kotschi, Stefan [VerfasserIn] |
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| | Kwon, Yun [VerfasserIn] |
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| | Le Thuc, Ophélia [VerfasserIn] |
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| | Hoffmann, Anne [VerfasserIn] |
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| | Gil-Lozano, Manuel [VerfasserIn] |
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| | Karbiener, Michael [VerfasserIn] |
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| | Higareda-Almaraz, Juan Carlos [VerfasserIn] |
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| | Khani, Sajjad [VerfasserIn] |
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| | Tews, Daniel [VerfasserIn] |
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| | Fischer-Posovszky, Pamela [VerfasserIn] |
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| | Sun, Wenfei [VerfasserIn] |
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| | Dong, Hua [VerfasserIn] |
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| | Ghosh, Adhideb [VerfasserIn] |
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| | Wolfrum, Christian [VerfasserIn] |
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| | Wabitsch, Martin [VerfasserIn] |
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| | Virtanen, Kirsi A [VerfasserIn] |
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| | Blüher, Matthias [VerfasserIn] |
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| | Nielsen, Søren [VerfasserIn] |
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| | Zeigerer, Anja [VerfasserIn] |
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| | García-Cáceres, Cristina [VerfasserIn] |
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| | Scheideler, Marcel [VerfasserIn] |
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| | Herzig, Stephan [VerfasserIn] |
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| | Bartelt, Alexander [VerfasserIn] |
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| Titel: | The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes |
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| Verf.angabe: | Maude Giroud, Stefan Kotschi, Yun Kwon, Ophélia Le Thuc, Anne Hoffmann, Manuel Gil-Lozano, Michael Karbiener, Juan Carlos Higareda-Almaraz, Sajjad Khani, Daniel Tews, Pamela Fischer-Posovszky, Wenfei Sun, Hua Dong, Adhideb Ghosh, Christian Wolfrum, Martin Wabitsch, Kirsi A Virtanen, Matthias Blüher, Søren Nielsen, Anja Zeigerer, Cristina García-Cáceres, Marcel Scheideler, Stephan Herzig & Alexander Bartelt |
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| E-Jahr: | 2023 |
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| Jahr: | 9 October 2023 |
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| Umfang: | 19 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 6 September 2023 ; Gesehen am 20.10.2023 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO reports |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2000 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 24(2023), 10 vom: Okt., Artikel-ID e57600, Seite 1-19 |
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| ISSN Quelle: | 1469-3178 |
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| Abstract: | Abstract Adipocytes are critical regulators of metabolism and energy balance. While white adipocyte dysfunction is a hallmark of obesity-associated disorders, thermogenic adipocytes are linked to cardiometabolic health. As adipocytes dynamically adapt to environmental cues by functionally switching between white and thermogenic phenotypes, a molecular understanding of this plasticity could help improving metabolism. Here, we show that the lncRNA Apoptosis associated transcript in bladder cancer (AATBC) is a human-specific regulator of adipocyte plasticity. Comparing transcriptional profiles of human adipose tissues and cultured adipocytes we discovered that AATBC was enriched in thermogenic conditions. Using primary and immortalized human adipocytes we found that AATBC enhanced the thermogenic phenotype, which was linked to increased respiration and a more fragmented mitochondrial network. Expression of AATBC in adipose tissue of mice led to lower plasma leptin levels. Interestingly, this association was also present in human subjects, as AATBC in adipose tissue was inversely correlated with plasma leptin levels, BMI, and other measures of metabolic health. In conclusion, AATBC is a novel obesity-linked regulator of adipocyte plasticity and mitochondrial function in humans. |
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| DOI: | doi:10.15252/embr.202357600 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.15252/embr.202357600 |
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| | kostenfrei: Volltext: https://www.embopress.org/doi/full/10.15252/embr.202357600 |
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| | DOI: https://doi.org/10.15252/embr.202357600 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adipocyte |
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| | mitochondrial dynamics |
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| | non-coding RNA |
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| | obesity |
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| | thermogenesis |
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| K10plus-PPN: | 1866729411 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes / Giroud, Maude [VerfasserIn]; 9 October 2023 (Online-Ressource)
