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| Verfasst von: | Kurz, Jennifer [VerfasserIn]  |
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| | Weiss, Anna-Carina [VerfasserIn] |
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| | Lüdtke, Timo H.-W. [VerfasserIn] |
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| | Deuper, Lena [VerfasserIn] |
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| | Trowe, Mark-Oliver [VerfasserIn] |
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| | Thiesler, Hauke [VerfasserIn] |
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| | Hildebrandt, Herbert [VerfasserIn] |
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| | Heineke, Jörg [VerfasserIn] |
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| | Duncan, Stephen A. [VerfasserIn] |
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| | Kispert, Andreas [VerfasserIn] |
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| Titel: | GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter |
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| Verf.angabe: | Jennifer Kurz, Anna-Carina Weiss, Timo H.-W. Lüdtke, Lena Deuper, Mark-Oliver Trowe, Hauke Thiesler, Herbert Hildebrandt, Joerg Heineke, Stephen A. Duncan and Andreas Kispert |
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| E-Jahr: | 2022 |
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| Jahr: | 29 July 2022 |
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| Umfang: | 13 S. |
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| Fussnoten: | Im Titel ist Myocd kursiv geschrieben ; Gesehen am 23.10.2023 |
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| Titel Quelle: | Enthalten in: Development |
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| Ort Quelle: | Cambridge : The Company of Biologists, 1953 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 149(2022), 15 vom: Aug., Artikel-ID dev200522, Seite 1-13 |
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| ISSN Quelle: | 1477-9129 |
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| Abstract: | Smooth muscle cells (SMCs) are a crucial component of the mesenchymal wall of the ureter, as they account for the efficient removal of the urine from the renal pelvis to the bladder by means of their contractile activity. Here, we show that the zinc-finger transcription factor gene Gata6 is expressed in mesenchymal precursors of ureteric SMCs under the control of BMP4 signaling. Mice with a conditional loss of Gata6 in these precursors exhibit a delayed onset and reduced level of SMC differentiation and peristaltic activity, as well as dilatation of the ureter and renal pelvis (hydroureternephrosis) at birth and at postnatal stages. Molecular profiling revealed a delayed and reduced expression of the myogenic driver gene Myocd, but the activation of signaling pathways and transcription factors previously implicated in activation of the visceral SMC program in the ureter was unchanged. Additional gain-of-function experiments suggest that GATA6 cooperates with FOXF1 in Myocd activation and SMC differentiation, possibly as pioneer and lineage-determining factors, respectively. |
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| DOI: | doi:10.1242/dev.200522 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1242/dev.200522 |
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| | kostenfrei: Volltext: https://journals.biologists.com/dev/article/149/15/dev200522/276151/GATA6-is-a-crucial-factor-for-Myocd-expression-in |
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| | DOI: https://doi.org/10.1242/dev.200522 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1867297493 |
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| Verknüpfungen: | → Zeitschrift |
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GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter / Kurz, Jennifer [VerfasserIn]; 29 July 2022 (Online-Ressource)
