Triflic acid catalyzed reductive coupling reactions of carbonyl compounds with O-, S-, and N-nucleophiles

• Verfasst von: Gellert, Beate A. [VerfasserIn]
• Verfasst von: Kahlcke, Nils [VerfasserIn]
• Verfasst von: Feurer, Markus [VerfasserIn]
• Verfasst von: Roth, Stefanie [VerfasserIn]
• Titel: Triflic acid catalyzed reductive coupling reactions of carbonyl compounds with O-, S-, and N-nucleophiles
• Verf.angabe: Dipl.-Chem. Beate A. Gellert, Dipl.-Chem. Nils Kahlcke, Dipl.-Chem. Markus Feurer, and Dr. Stefanie Roth
• E-Jahr: 2011
• Jahr: September 16, 2011
• Umfang: 7 S.
• Fussnoten: Gesehen am 23.10.2023
• Titel Quelle: Enthalten in: Chemistry - a European journal
• Ort Quelle: Weinheim : Wiley-VCH, 1995
• Jahr Quelle: 2011
• Band/Heft Quelle: 17(2011), 43 vom: Okt., Seite 12203-12209
• ISSN Quelle: 1521-3765
• DOI: doi:10.1002/chem.201101819
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Brønsted acids
• Sach-SW: reductive etherification
• Sach-SW: silanes
• Sach-SW: sulfonamides
• Sach-SW: thioethers
• K10plus-PPN: 186726885X

Abstract

Highly efficient metal-free reductive coupling reactions of aldehydes and ketones with a range of nucleophiles in the presence of triflic acid (1-5 mol %) as the catalyst are presented. The reactions can be performed at ambient temperature without exclusion of moisture or air. A range of symmetrical and unsymmetrical ethers were obtained by this method in high yields and short reaction times. For the first time, the influence of additional functionalization has been studied. Furthermore, the formation of thioethers from ketones (by addition of unmodified thiols) and of sulfonamides from either aldehydes or ketones has been achieved under catalytic conditions.