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Status: Bibliographieeintrag

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Verfasst von:Schaefer, Tabea [VerfasserIn]   i
 Greive, Svenja [VerfasserIn]   i
 Mencl, Stine [VerfasserIn]   i
 Heiland, Sabine [VerfasserIn]   i
 Kramer, Martin [VerfasserIn]   i
 Möhlenbruch, Markus Alfred [VerfasserIn]   i
 Kleinschnitz, Christoph [VerfasserIn]   i
 Bendszus, Martin [VerfasserIn]   i
 Vollherbst, Dominik [VerfasserIn]   i
Titel:Iatrogenic air embolisms during endovascular interventions
Titelzusatz:impact of origin and number of air bubbles on cerebral infarctions
Verf.angabe:Tabea C. Schaefer, Svenja Greive, Stine Mencl, Sabine Heiland, Martin Kramer, Markus A. Möhlenbruch, Christoph Kleinschnitz, Martin Bendszus, Dominik F. Vollherbst
Jahr:2023
Umfang:11 S.
Illustrationen:Illustrationen
Fussnoten:Vorab online veröffentlicht: 04. September 2023 ; Gesehen am 27.10.2023
Titel Quelle:Enthalten in: Clinical neuroradiology
Ort Quelle:München : Urban & Vogel, 2006
Jahr Quelle:2024
Band/Heft Quelle:34(2024), 1, Seite 135-145
ISSN Quelle:1869-1447
 1615-6706
Abstract:Purpose: Cerebral infarctions caused by air embolisms (AE) are a feared risk in endovascular procedures; however, the relevance and pathophysiology of these AEs is still largely unclear. The objective of this study was to investigate the impact of the origin (aorta, carotid artery or right atrium) and number of air bubbles on cerebral infarctions in an experimental in vivo model. Methods: In 20 rats 1200 or 2000 highly calibrated micro air bubbles (MAB) with a size of 85µm were injected at the aortic valve (group Ao), into the common carotid artery (group CA) or into the right atrium (group RA) using a microcatheter via a transfemoral access, resembling endovascular interventions in humans. Magnetic resonance imaging (MRI) using a 9.4T system was performed 1h after MAB injection followed by finalization. Results: The number (5.5 vs. 5.5 median) and embolic patterns of infarctions did not significantly differ between groups Ao and CA. The number of infarctions were significantly higher comparing 2000 and 1200 injected MABs (6 vs. 4.5; p< 0.001). The infarctions were significantly larger for group CA (median infarction volume: 0.41mm3 vs. 0.19mm3; p< 0.001). In group RA and in the control group no infarctions were detected. Histopathological analyses showed early signs of ischemic stroke. Conclusion: Iatrogenic AEs originating at the ascending aorta cause a similar number and pattern of cerebral infarctions compared to those with origin at the carotid artery. These findings underline the relevance and potential risk of AE occurring during endovascular interventions at the aortic valve and ascending aorta.
DOI:doi:10.1007/s00062-023-01347-2
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1007/s00062-023-01347-2
 DOI: https://doi.org/10.1007/s00062-023-01347-2
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cerebral infarction
 Endovascular interventions
 Gas embolism
 TAVI
 TEVAR
K10plus-PPN:1868561186
Verknüpfungen:→ Zeitschrift

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