Single versus bilateral external ventricular drainage for intraventricular fibrinolysis in severe ventricular haemorrhage

• Verfasst von: Staykov, Dimitre [VerfasserIn]
• Verfasst von: Huttner, H. B. [VerfasserIn]
• Verfasst von: Lunkenheimer, J. [VerfasserIn]
• Verfasst von: Volbers, B. [VerfasserIn]
• Verfasst von: Struffert, T. [VerfasserIn]
• Verfasst von: Doerfler, A. [VerfasserIn]
• Verfasst von: Ganslandt, O. [VerfasserIn]
• Verfasst von: Jüttler, Eric [VerfasserIn]
• Verfasst von: Schwab, S. [VerfasserIn]
• Verfasst von: Bardutzky, Jürgen [VerfasserIn]
• Titel: Single versus bilateral external ventricular drainage for intraventricular fibrinolysis in severe ventricular haemorrhage
• Verf.angabe: D. Staykov, H. B. Huttner, J. Lunkenheimer, B. Volbers, T. Struffert, A. Doerfler, O. Ganslandt, E. Juettler, S. Schwab, J. Bardutzky
• E-Jahr: 2010
• Jahr: 2010 Jan
• Umfang: 4 S.
• Fussnoten: Gesehen am 27.10.2023
• Titel Quelle: Enthalten in: Journal of neurology, neurosurgery, and psychiatry
• Ort Quelle: London : BMJ Publishing Group, 1944
• Jahr Quelle: 2010
• Band/Heft Quelle: 81(2010), 1, Seite 105-108
• ISSN Quelle: 1468-330X
• DOI: doi:10.1136/jnnp.2008.168427
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cerebral Hemorrhage
• Sach-SW: Cerebrospinal Fluid Shunts
• Sach-SW: Drainage
• Sach-SW: Fibrinolytic Agents
• Sach-SW: Hematoma
• Sach-SW: Humans
• Sach-SW: Injections, Intraventricular
• Sach-SW: Middle Aged
• Sach-SW: Tomography, X-Ray Computed
• Sach-SW: Treatment Outcome
• K10plus-PPN: 186856388X

Abstract

BACKGROUND: Intraventricular fibrinolysis (IVF) through bilateral external ventricular drains (EVD) may provide better access of the thrombolytic agent to the intraventricular clot, potentially influencing clot clearance and outcome. - METHODS: Patients with spontaneous ganglionic intracerebral haemorrhage (ICH)<40 cm(3) and intraventricular haemorrhage (IVH) with acute hydrocephalus have been treated with IVF. The decision for placement of one or two EVDs has been left to the discretion of the treating physician. CT volumetry, the effects on cerebrospinal fluid (CSF) circulation and outcome at 3 months have been analysed for patients with one (group I, n = 13) or two EVDs (group II, n = 14). - RESULTS: No difference was found in clot resolution between the two groups (clot half life 2.1 (SD 1.2) vs 2.4 (1.3) days). A separate analysis of the third and fourth ventricle clearance was similar (1.6 (0.6) versus 1.8 (0.8) days), indicating no difference in reconstitution of CSF circulation. A trend towards a longer EVD duration and higher infection rate was found in the bilateral EVD group. No difference was found in outcome at 3 months. - CONCLUSIONS: Our results do not support the use of bilateral EVDs for IVF in patients with severe IVH.