| |  Online-Ressource |
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| Verfasst von: | Rotterdam, Jil [VerfasserIn]  |
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| | Thiaucourt, Margot [VerfasserIn] |
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| | Weiß, Christel [VerfasserIn] |
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| | Schwaab, Juliana [VerfasserIn] |
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| | Reiter, Andreas [VerfasserIn] |
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| | Kreil, Sebastian [VerfasserIn] |
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| | Steiner, Laurenz [VerfasserIn] |
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| | Fenchel, Sebastian [VerfasserIn] |
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| | Popp, Henning [VerfasserIn] |
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| | Hofmann, Wolf-Karsten [VerfasserIn] |
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| | Bonatz, Karin [VerfasserIn] |
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| | Gerhards, Catharina [VerfasserIn] |
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| | Neumaier, Michael [VerfasserIn] |
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| | Klein, Stefan [VerfasserIn] |
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| | Rao, Sonika [VerfasserIn] |
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| | Jawhar, Mohamad [VerfasserIn] |
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| | Saußele, Susanne [VerfasserIn] |
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| Titel: | Definition of factors associated with negative antibody response after COVID-19 vaccination in patients with hematological diseases |
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| Verf.angabe: | Jil Rotterdam, Margot Thiaucourt, Christel Weiss, Juliana Schwaab, Andreas Reiter, Sebastian Kreil, Laurenz Steiner, Sebastian Fenchel, Henning D. Popp, Wolf-Karsten Hofmann, Karin Bonatz, Catharina Gerhards, Michael Neumaier, Stefan A. Klein, Sonika Rao, Mohamad Jawhar, Susanne Saussele |
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| E-Jahr: | 2022 |
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| Jahr: | 21 May 2022 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 31.10.2023 |
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| Titel Quelle: | Enthalten in: Annals of hematology |
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| Ort Quelle: | Berlin : Springer, 1955 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 101(2022), 8 vom: Aug., Seite 1825-1834 |
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| ISSN Quelle: | 1432-0584 |
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| Abstract: | COVID-19 in patients with hematological diseases is associated with a high mortality. Moreover, preventive vaccination demonstrated reduced efficacy and the knowledge on influencing factors is limited. In this single-center study, antibody levels of the SARS-CoV-2 spike protein were measured ≥ 2 weeks after 2nd COVID-19 vaccination with a concentration ≥ 0.8 U/mL considered positive. Between July and October 2021, in a total of 373 patients (median age 64 years, 44% women) with myeloid neoplasms (n = 214, 57%), lymphoid neoplasms (n = 124, n = 33%), and other diseases (n = 35, 10%), vaccination was performed with BNT162b2 (BioNTech), mRNA-1273 (Moderna), ChADOx1 (AstraZeneca), or a combination. A total of 229 patients (61%) were on active therapy within 3 months prior vaccination and 144 patients (39%) were previously treated or treatment naïve. Vaccination-related antibody response was negative in 56/373 patients (15%): in 39/124 patients with lymphoid neoplasms, 13/214 with myeloid neoplasms, and 4/35 with other diseases. Active treatment per se was not correlated with negative response. However, rituximab and BTK inhibitor treatment were correlated significantly with a negative vaccination response, whereas younger age and chronic myeloid leukemia (CML) disease were associated with positive response. In addition, 5 of 6 patients with myeloproliferative neoplasm (MPN) and negative vaccination response were on active treatment with ruxolitinib. In conclusion, a remarkable percentage of patients with hematological diseases had no response after 2nd COVID-19 vaccination. Multivariable analysis revealed important factors associated with response to vaccination. The results may serve as a guide for better protection and surveillance in this vulnerable patient cohort. |
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| DOI: | doi:10.1007/s00277-022-04866-z |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1007/s00277-022-04866-z |
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| | kostenfrei: Volltext: https://link.springer.com/article/10.1007/s00277-022-04866-z |
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| | DOI: https://doi.org/10.1007/s00277-022-04866-z |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | COVID-19 vaccination |
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| | Hematological diseases/disorders |
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| | SARS-CoV-2 |
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| | Seroconversion |
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| K10plus-PPN: | 1868847357 |
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| Verknüpfungen: | → Zeitschrift |
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Definition of factors associated with negative antibody response after COVID-19 vaccination in patients with hematological diseases / Rotterdam, Jil [VerfasserIn]; 21 May 2022 (Online-Ressource)
