Rapidly progressive IgA nephropathy with anti-myeloperoxidase antibodies benefits from immunosuppression

• Verfasst von: Allmaras, Eberhard [VerfasserIn]
• Verfasst von: Nowack, R [VerfasserIn]
• Verfasst von: Andrassy, Konrad [VerfasserIn]
• Verfasst von: Waldherr, Rüdiger [VerfasserIn]
• Verfasst von: Woude, Fokko J. van der [VerfasserIn]
• Verfasst von: Ritz, Eberhard [VerfasserIn]
• Titel: Rapidly progressive IgA nephropathy with anti-myeloperoxidase antibodies benefits from immunosuppression
• Verf.angabe: E Allmaras, R Nowack, K Andrassy, R Waldherr, F van der Woude, E Ritz
• E-Jahr: 1997
• Jahr: 01 Nov 1997
• Umfang: 5 S.
• Fussnoten: Gesehen am 02.11.2023
• Titel Quelle: Enthalten in: Clinical nephrology
• Ort Quelle: Deisenhofen, Munich : Dustri-Verl. Feistle, 2002
• Jahr Quelle: 1997
• Band/Heft Quelle: 48(1997), 5, Seite 269-273
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1868986438

Abstract

Clinical observationsThree patients with previous pulmonary infections were recently admitted with rapidly progressive renal failure. Renal biopsy showed crescentic glomerulonephritis with deposits of IgA, C3c and C3d. Serology disclosed P-ANCA with high-titer anti-myeloperoxidase antibodies. Two out of three patients became dialysis dependent despite immunosuppression with methylprednisolone and cyclophosphamide. Renal function improved in both patients after 2 weeks and 9 months, respectively, permitting termination of hemodialysis. All patients benefited from immunosuppressive treatment which is currently still being continued.ConclusionThe data suggest that early immunosuppression is beneficial in patients presenting with crescentic rapidly progressive IgA GN and anti-myeloperoxidase antibodies, which may represent a novel subset of crescentic IgA GN associated with high-titer anti-myeloperoxidase antibodies constituting an overlap group between microscopic polyangiitis and IgA GN.