Cell-cell interactions drive metastasis of circulating tumor microemboli

• Verfasst von: Tao, Jianxin [VerfasserIn]
• Verfasst von: Zhu, Lei [VerfasserIn]
• Verfasst von: Yakoub, Mina [VerfasserIn]
• Verfasst von: Reißfelder, Christoph [VerfasserIn]
• Verfasst von: Loges, Sonja [VerfasserIn]
• Verfasst von: Schölch, Sebastian [VerfasserIn]
• Titel: Cell-cell interactions drive metastasis of circulating tumor microemboli
• Verf.angabe: Jianxin Tao, Lei Zhu, Mina Yakoub, Christoph Reißfelder, Sonja Loges, and Sebastian Schölch
• E-Jahr: 2022
• Jahr: August 03 2022
• Umfang: 11 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 06.11.2023
• Titel Quelle: Enthalten in: Cancer research
• Ort Quelle: Philadelphia, Pa. : AACR, 1916
• Jahr Quelle: 2022
• Band/Heft Quelle: 82(2022), 15 vom: Aug., Seite 2661-2671
• ISSN Quelle: 1538-7445
• DOI: doi:10.1158/0008-5472.CAN-22-0906
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1869368223

Abstract

Circulating tumor cells are the cellular mediators of distant metastasis in solid malignancies. Their metastatic potential can be augmented by clustering with other tumor cells or nonmalignant cells, forming circulating tumor microemboli (CTM). Cell-cell interactions are key regulators within CTM that convey enhanced metastatic properties, including improved cell survival, immune evasion, and effective extravasation into distant organs. However, the cellular and molecular mechanism of CTM formation, as well as the biology of interactions between tumor cells and immune cells, platelets, and stromal cells in the circulation, remains to be determined. Here, we review the current literature on cell-cell interactions in homotypic and heterotypic CTM and provide perspectives on therapeutic strategies to attenuate CTM-mediated metastasis by targeting cell-cell interactions.