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| Verfasst von: | Valent, Peter [VerfasserIn]  |
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| | Hartmann, Karin [VerfasserIn] |
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| | Schwaab, Juliana [VerfasserIn] |
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| | Alvarez-Twose, Ivan [VerfasserIn] |
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| | Brockow, Knut [VerfasserIn] |
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| | Bonadonna, Patrizia [VerfasserIn] |
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| | Hermine, Olivier [VerfasserIn] |
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| | Niedoszytko, Marek [VerfasserIn] |
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| | Carter, Melody C. [VerfasserIn] |
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| | Hoermann, Gregor [VerfasserIn] |
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| | Sperr, Wolfgang R. [VerfasserIn] |
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| | Butterfield, Joseph H. [VerfasserIn] |
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| | Ustun, Celalettin [VerfasserIn] |
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| | Zanotti, Roberta [VerfasserIn] |
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| | Radia, Deepti H. [VerfasserIn] |
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| | Castells, Mariana [VerfasserIn] |
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| | Triggiani, Massimo [VerfasserIn] |
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| | Schwartz, Lawrence B. [VerfasserIn] |
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| | Orfao, Alberto [VerfasserIn] |
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| | George, Tracy I. [VerfasserIn] |
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| | Sotlar, Karl [VerfasserIn] |
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| | Gotlib, Jason [VerfasserIn] |
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| | Reiter, Andreas [VerfasserIn] |
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| | Horny, Hans-Peter [VerfasserIn] |
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| | Arock, Michel [VerfasserIn] |
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| | Akin, Cem [VerfasserIn] |
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| | Metcalfe, Dean D. [VerfasserIn] |
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| Titel: | Personalized management strategies in mast cell disorders |
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| Titelzusatz: | ECNM-AIM user’s guide for daily clinical practice : clinical management review |
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| Verf.angabe: | Peter Valent, Karin Hartmann, Juliana Schwaab, Ivan Alvarez-Twose, Knut Brockow, Patrizia Bonadonna, Olivier Hermine, Marek Niedoszytko, Melody C. Carter, Gregor Hoermann, Wolfgang R. Sperr, Joseph H. Butterfield, Celalettin Ustun, Roberta Zanotti, Deepti H. Radia, Mariana Castells, Massimo Triggiani, Lawrence B. Schwartz, Alberto Orfao, Tracy I. George, Karl Sotlar, Jason Gotlib, Andreas Reiter, Hans-Peter Horny, Michel Arock, Cem Akin, and Dean D. Metcalfe |
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| E-Jahr: | 2022 |
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| Jahr: | August 2022 |
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| Umfang: | 20 S. |
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| Fussnoten: | Online verfügbar: 25 March 2022, Artikelversion: 9 August 2022 ; Gesehen am 07.11.2023 |
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| Titel Quelle: | Enthalten in: The journal of allergy and clinical immunology. In practice |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2013 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 10(2022), 8 vom: Aug., Seite 1999-2012.e6 |
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| ISSN Quelle: | 2213-2201 |
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| Abstract: | Mastocytosis is a myeloid neoplasm defined by expansion and focal accumulation of clonal mast cells (MCs) in one or more organs. The disease exhibits a complex pathology and may be complicated by MC activation, bone abnormalities, neurological problems, gastrointestinal symptoms, and/or hematologic progression. The World Health Organization divides mastocytosis into cutaneous forms, systemic mastocytosis (SM) and MC sarcoma. In most patients with SM, somatic mutations in KIT are detected. Patients with indolent SM have a normal to near-normal life expectancy, whereas patients with advanced SM, including aggressive SM and MC leukemia, have a poor prognosis. In those with advanced SM, multiple somatic mutations and an associated hematologic neoplasm may be detected. Mediator-related symptoms can occur in any type of mastocytosis. Symptoms may be mild, severe, or even life-threatening. In patients with severe acute symptoms, an MC activation syndrome may be diagnosed. In these patients, relevant comorbidities include IgE-dependent and IgE-independent allergies. Management of patients with SM is an emerging challenge in daily practice and requires in-depth knowledge and a multidisciplinary and personalized approach with selection of appropriate procedures and interventions. In this article, we review the current knowledge on SM and MC activation syndrome, with emphasis on multidisciplinary aspects in diagnosis and patient-specific management. In addition, we provide a user’s guide for application of markers, algorithms, prognostic scores, and treatments for use in daily practice. |
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| DOI: | doi:10.1016/j.jaip.2022.03.007 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.jaip.2022.03.007 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2213219822002811 |
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| | DOI: https://doi.org/10.1016/j.jaip.2022.03.007 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Allergy |
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| | IgE |
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| | KIT |
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| | Mast cells |
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| | MCAS |
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| | Personalized medicine |
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| | Tryptase |
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| K10plus-PPN: | 1869490886 |
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| Verknüpfungen: | → Zeitschrift |
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Personalized management strategies in mast cell disorders / Valent, Peter [VerfasserIn]; August 2022 (Online-Ressource)
