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| Verfasst von: | Schrottenberg, Christoph von [VerfasserIn]  |
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| | Deeg, Susanne [VerfasserIn] |
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| | Weiß, Christel [VerfasserIn] |
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| | Adam, Rüdiger [VerfasserIn] |
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| | Wessel, Lucas [VerfasserIn] |
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| | Boettcher, Michael [VerfasserIn] |
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| | Zahn, Katrin [VerfasserIn] |
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| Titel: | Long-term evaluation of gastroesophageal reflux in neonates with and without preventive anti-reflux surgery at the time of congenital diaphragmatic hernia repair |
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| Verf.angabe: | Christoph von Schrottenberg, Susanne Deeg, Christel Weiss, Rüdiger Adam, Lucas M. Wessel, Michael Boettcher and Katrin B. Zahn |
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| E-Jahr: | 2022 |
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| Jahr: | 29 July 2022 |
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| Umfang: | 13 S. |
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| Fussnoten: | Dieser Artikel gehört zum Special issue: Evaluation of long-term outcomes of congenital diaphragmatic hernia ; Gesehen am 07.11.2023 |
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| Titel Quelle: | Enthalten in: Children |
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| Ort Quelle: | Basel : MDPI, 2013 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 9(2022), 8, Artikel-ID 1137, Seite 1-13 |
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| ISSN Quelle: | 2227-9067 |
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| Abstract: | One potential comorbidity after congenital diaphragmatic hernia (CDH) is gastroesophageal reflux (GER), which can have a substantial effect on patients’ quality of life, thriving, and complications later in life. Efforts have been made to reduce gastroesophageal reflux with a preventive anti-reflux procedure at the time of CDH repair. In this follow-up study of neonates participating in a primary RCT study on preventive anti-reflux surgery, symptoms of GER were assessed longitudinally. Long-term data with a median follow-up time of ten years was available in 66 patients. Thirty-one neonates received an initial fundoplication. Secondary anti-reflux surgery was necessary in 18% and only in patients with large defects. It was required significantly more often in patients with intrathoracic herniation of liver (p = 0.015) and stomach (p = 0.019) and patch repair (p = 0.03). Liver herniation was the only independent risk factor identified in multivariate regression analysis. Primary fundopexy and hemifundoplication did not reveal a protective effect regarding the occurrence of GER symptoms, the need for secondary antireflux surgery or the gain of body weight regardless of defect size neither in the short nor in the long term. Symptoms of GER must be assessed carefully especially in children with large defects, as these are prone to require secondary anti-reflux surgery in the long-term. Routine evaluation of GER including endoscopy and impedance measurement should be recommended especially for high-risk patients. |
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| DOI: | doi:10.3390/children9081137 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/children9081137 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2227-9067/9/8/1137 |
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| | DOI: https://doi.org/10.3390/children9081137 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CDH |
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| | congenital diaphragmatic hernia |
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| | fundoplication |
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| | gastroesophageal reflux |
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| | GER |
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| | long-term follow-up |
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| | preventive anti-reflux surgery |
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| K10plus-PPN: | 1869496876 |
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| Verknüpfungen: | → Zeitschrift |
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Long-term evaluation of gastroesophageal reflux in neonates with and without preventive anti-reflux surgery at the time of congenital diaphragmatic hernia repair / Schrottenberg, Christoph von [VerfasserIn]; 29 July 2022 (Online-Ressource)
