| |  Online-Ressource |
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| Verfasst von: | Bayramov, Bayram [VerfasserIn]  |
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| | Bayramov, Nuru [VerfasserIn] |
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| | Aslanov, Hazi [VerfasserIn] |
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| | Karimova, Nigar [VerfasserIn] |
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| | Gasimov, Karim [VerfasserIn] |
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| | Shahmuradov, Ilham [VerfasserIn] |
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| | Reißfelder, Christoph [VerfasserIn] |
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| | Yagublu, Vugar [VerfasserIn] |
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| Titel: | Association of miR-149 T>C and miR-196a2 C>T polymorphisms with colorectal cancer susceptibility |
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| Titelzusatz: | a case-control study |
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| Verf.angabe: | Bayram Bayramov, Nuru Bayramov, Hazi Aslanov, Nigar Karimova, Karim Gasimov, Ilham Shahmuradov, Christoph Reißfelder and Vugar Yagublu |
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| Jahr: | 2023 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Veröffentlicht: 23. August 2023 ; Gesehen am 07.11.2023 |
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| Titel Quelle: | Enthalten in: Biomedicines |
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| Ort Quelle: | Basel : MDPI, 2013 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 11(2023), 9, Artikel-ID 2341, Seite 1-12 |
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| ISSN Quelle: | 2227-9059 |
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| Abstract: | The principal aim of the current study was to investigate the relationship between miR-149 T>C (rs2292832) and miR-196a2 C>T (rs11614913) small non-coding RNA polymorphisms and the risk of developing CRC in the Azerbaijani population. The study included 120 patients diagnosed with CRC and 125 healthy individuals. Peripheral blood samples were collected from all the subjects in EDTA tubes and DNA extraction was performed by salting out. Polymorphisms were determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. While comparing without gender distinction no statistical correlation was found between the heterozygous TC (OR = 0.66; 95% CI = 0.37-1.15; p = 0.142), mutant CC (OR = 1.23; 95% CI = 0.62-2.45; p = 0.550), and mutant C (OR = 1.03; 95% CI = 0.72-1.49; p = 0.859) alleles of the miR-149 gene and the CT (OR = 1.23; 95% CI = 0.69-2.20; p = 0.485), mutant TT (OR = 1.29; 95% CI = 0.67-2.47; p = 0.452), and mutant T (OR = 1.17; 95% CI = 0.82-1.67; p = 0.388) alleles of the miR-196a2 gene and the risk of CRC. However, among women, miR-149 TC (OR = 0.43; 95% CI = 0.19-1.01; p = 0.048) correlated with a reduced risk of CRC, whereas miR-196a2 CT (OR = 2.77; 95% CI = 1.13-6.79; p = 0.025) correlated with an increased risk of CRC. Our findings indicated that miR-149 T>C (rs2292832) might play a protective role in the development of CRC in female patients, whereas the miR-196a2 (rs11614913) polymorphism is associated with an increased risk of CRC in women in the Azerbaijani population, highlighting the importance of gender dimorphism in cancer etiology. |
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| DOI: | doi:10.3390/biomedicines11092341 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/biomedicines11092341 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2227-9059/11/9/2341 |
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| | DOI: https://doi.org/10.3390/biomedicines11092341 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | colorectal cancer |
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| | microRNA |
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| | non-coding RNA |
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| | PCR-RFLP |
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| | polymorphism |
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| K10plus-PPN: | 1869526627 |
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| Verknüpfungen: | → Zeitschrift |
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Association of miR-149 T>C and miR-196a2 C>T polymorphisms with colorectal cancer susceptibility / Bayramov, Bayram [VerfasserIn]; 2023 (Online-Ressource)
