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| Verfasst von: | Neumaier, Michael [VerfasserIn]  |
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| | Giesler, Sophie [VerfasserIn] |
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| | Ast, Volker [VerfasserIn] |
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| | Römer, Mathis [VerfasserIn] |
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| | Voß, Timo-Daniel [VerfasserIn] |
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| | Reinz, Eileen [VerfasserIn] |
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| | Costina, Victor [VerfasserIn] |
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| | Schmelz, Martin [VerfasserIn] |
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| | Nürnberg, Elina [VerfasserIn] |
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| | Nittka, Stefanie [VerfasserIn] |
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| | Leppä, Aino-Maija [VerfasserIn] |
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| | Rudolf, Rüdiger [VerfasserIn] |
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| | Trumpp, Andreas [VerfasserIn] |
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| | Fuchs, Tina [VerfasserIn] |
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| Titel: | Opsonization-independent antigen-specific recognition by myeloid phagocytes expressing monoclonal antibodies |
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| Verf.angabe: | Michael Neumaier, Sophie Giesler, Volker Ast, Mathis Roemer, Timo-Daniel Voß, Eileen Reinz, Victor Costina, Martin Schmelz, Elina Nürnberg, Stefanie Nittka, Aino-Maija Leppä, Ruediger Rudolf, Andreas Trumpp, Tina Fuchs |
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| E-Jahr: | 2023 |
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| Jahr: | Sep 2023 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 01. September 2023 ; Gesehen am 09.11.2023 |
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| Titel Quelle: | Enthalten in: Science advances |
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| Ort Quelle: | Washington, DC [u.a.] : Assoc., 2015 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 9(2023), 35, Artikel-ID eadg181, Seite 1-12 |
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| ISSN Quelle: | 2375-2548 |
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| Abstract: | This report demonstrates a novel class of innate immune cells designated “variable immunoreceptor-expressing myeloids” (VIREMs). Using single-cell transcriptomics and genome-wide epigenetic profiling, we establish that VIREMs are myeloid cells unrelated to lymphocytes. We visualize the phenotype of B-VIREMs that are capable of genetically recombining and expressing antibody genes, the exclusive hallmark function of B lymphocytes. These cells, designated B-VIREMs, display monoclonal antibody cell surface signatures and regularly circulate in the blood of healthy individuals. Single-cell data reveal clonal expansion of circulating B-VIREMs as a dynamic response to disease stimuli. Live-cell imaging models suggest that B-VIREMs load their own Fc receptors with endogenous antibodies during vesicle transport to the cell surface. A first cloned B-VIREM-derived antibody (Vab1) specifically binds stomatin, a ubiquitous scaffold protein that is strictly expressed intracellularly, allowing Vab1-bearing macrophages to phagocytose cell debris without requiring prior opsonization. Our results suggest important antigen-specific tissue maintenance functionalities in these innate immune cells. |
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| DOI: | doi:10.1126/sciadv.adg1812 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Resolving-System: https://doi.org/10.1126/sciadv.adg1812 |
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| | DOI: https://doi.org/10.1126/sciadv.adg1812 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1866637614 |
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| Verknüpfungen: | → Zeitschrift |
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Opsonization-independent antigen-specific recognition by myeloid phagocytes expressing monoclonal antibodies / Neumaier, Michael [VerfasserIn]; Sep 2023 (Online-Ressource)
