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Status: Bibliographieeintrag

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Verfasst von:Osborne, John P. [VerfasserIn]   i
 Edwards, Stuart W. [VerfasserIn]   i
 Alber, Fabienne Dietrich [VerfasserIn]   i
 Hancock, Eleanor [VerfasserIn]   i
 Johnson, Anthony L. [VerfasserIn]   i
 Kennedy, Colin R. [VerfasserIn]   i
 Likeman, Marcus [VerfasserIn]   i
 Lux, Andrew L. [VerfasserIn]   i
 Mackay, Mark [VerfasserIn]   i
 Mallick, Andrew [VerfasserIn]   i
 Newton, Richard W. [VerfasserIn]   i
 Nolan, Melinda [VerfasserIn]   i
 Pressler, Ronit [VerfasserIn]   i
 Rating, Dietz [VerfasserIn]   i
 Schmitt, Bernhard [VerfasserIn]   i
 Verity, Christopher M. [VerfasserIn]   i
 O'Callaghan, FinbarJ. K. [VerfasserIn]   i
Titel:Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome?
Titelzusatz:A prospective analysis of data embedded within two randomised controlled trials
Verf.angabe:John P. Osborne, Stuart W. Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L. Johnson, Colin R. Kennedy, Marcus Likeman, Andrew L. Lux, Mark Mackay, Andrew Mallick, Richard W. Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M. Verity, FinbarJ.K. O'Callaghan
E-Jahr:2023
Jahr:6 January 2023
Umfang:7 S.
Fussnoten:Online verfügbar 26 December 2022, Version des Artikels 6 January 2023 ; Gesehen am 13.11.2023
Titel Quelle:Enthalten in: European journal of paediatric neurology
Ort Quelle:Burlington, Mass. : Harcourt, 1997
Jahr Quelle:2023
Band/Heft Quelle:42(2023) vom: Jan., Seite 110-116
ISSN Quelle:1532-2130
Abstract:Objective - To report a prospectively planned analysis of two randomised controlled trials with embedded comparisons of prednisolone versus tetracosactide depot for the treatment of infantile epileptic spasms syndrome (IESS). - Methods - Individual patient data from patients randomly allocated to prednisolone or tetracosactide depot were analysed from two trials (UKISS, ICISS). The comparison was embedded within trials in which some patients also received vigabatrin but only patients receiving monotherapy with randomly allocated hormonal treatments are included in this analysis. The main outcome was cessation of spasms (Days 13-14 after randomisation). Lead time to treatment and underlying aetiology were taken into account. Cessation of spasms on Days 14-42 inclusive, electroclinical response (EEG Day 14), plus developmental and epilepsy outcomes (at 14 months in UKISS and 18 months in ICISS) are also reported. Minimum treatment was prednisolone 40 mg per day for two weeks or tetracosactide depot 0·5 mg IM on alternate days for two weeks, all followed by a reducing dose of prednisolone over two weeks. - Results - 126 infants were included in this study. On tetracosactide depot, 47 of 62 (76%) were free of spasms on Days 13-14 compared to 43 of 64 (67%) on prednisolone (difference 9%, 95% CI -7·2% to +25·2%, chi square 1·15, p = 0·28). For Day 14-42 cessation of spasms, on tetracosactide depot, 41 of 61 (67%) were free of spasms compared to 35 of 62 (56%) on prednisolone (difference 11%, 95% CI -6·4% to +28·4%, chi square 1·51, p = 0·22). There was no significant difference in mean VABS score between infants who received prednisolone compared with those who received tetracosactide depot (74·8 (SD 18·3) versus 78·0 (SD 20·2) t = −0·91 p = 0·36). The proportion with ongoing epilepsy at the time of developmental assessment was 20 of 61 (33%) in the tetracosactide group compared with 26 out of 63 (41%) in the prednisolone group (difference 8%, 95% CI -9·2% to +25·2%, Chi [2] 0·95, p = 0·33). - Significance - With hormone monotherapy, either prednisolone or tetracosactide depot may be recommended for infantile epileptic spasms syndrome.
DOI:doi:10.1016/j.ejpn.2022.12.007
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.ejpn.2022.12.007
 Volltext: https://www.sciencedirect.com/science/article/pii/S1090379822001726
 DOI: https://doi.org/10.1016/j.ejpn.2022.12.007
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Epileptic spasms
 Infantile epileptic spasm syndrome
 Infantile spasms
 International collaborative infantile spasms study
 Prednisolone
 Randomised controlled trial
 Tetracosactide
 United Kingdom Infantile spasms study
 West syndrome
K10plus-PPN:187010126X
Verknüpfungen:→ Zeitschrift

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