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Verfasst von:Eichler, Martin [VerfasserIn]   i
 Hentschel, Leopold [VerfasserIn]   i
 Singer, Susanne [VerfasserIn]   i
 Hornemann, Beate [VerfasserIn]   i
 Richter, Stephan [VerfasserIn]   i
 Hofbauer, Christine [VerfasserIn]   i
 Hohenberger, Peter [VerfasserIn]   i
 Kasper, Bernd [VerfasserIn]   i
 Andreou, Dimosthenis [VerfasserIn]   i
 Pink, Daniel [VerfasserIn]   i
 Jakob, Jens [VerfasserIn]   i
 Grützmann, Robert [VerfasserIn]   i
 Fung, Stephen [VerfasserIn]   i
 Wardelmann, Eva [VerfasserIn]   i
 Arndt, Karin [VerfasserIn]   i
 Hermes-Moll, Kerstin [VerfasserIn]   i
 Schoffer, Olaf [VerfasserIn]   i
 Fried, Marius [VerfasserIn]   i
 Jambor, Helena K. [VerfasserIn]   i
 Weitz, Jürgen [VerfasserIn]   i
 Schaser, Klaus-Dieter [VerfasserIn]   i
 Bornhäuser, Martin [VerfasserIn]   i
 Schmitt, Jochen [VerfasserIn]   i
 Schuler, Markus K. [VerfasserIn]   i
Titel:Health related quality of life over time in german sarcoma patients
Titelzusatz:an analysis of associated factors - results of the PROSa study
Verf.angabe:Martin Eichler, Leopold Hentschel, Susanne Singer, Beate Hornemann, Stephan Richter, Christine Hofbauer, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jens Jakob, Robert Grützmann, Stephen Fung, Eva Wardelmann, Karin Arndt, Kerstin Hermes-Moll, Olaf Schoffer, Marius Fried, Helena K. Jambor, Jürgen Weitz, Klaus-Dieter Schaser, Martin Bornhäuser, Jochen Schmitt and Markus K. Schuler
Jahr:2023
Umfang:14 S.
Fussnoten:Veröffentlicht: 29. August 2023 ; Gesehen am 14.11.2023
Titel Quelle:Enthalten in: Frontiers in endocrinology
Ort Quelle:Lausanne : Frontiers Research Foundation, 2010
Jahr Quelle:2023
Band/Heft Quelle:14(2023), Artikel-ID 1166838, Seite 1-14
ISSN Quelle:1664-2392
Abstract:IntroductionSarcomas are rare cancers and very heterogeneous in their location, histological subtype, and treatment. Health-Related Quality of Life (HRQoL) of sarcoma patients has rarely been investigated in longitudinal studies.MethodsHere, we assessed adult sarcoma patients and survivors between September 2017 and February 2020, and followed-up for one year in 39 study centers in Germany. Follow-up time points were 6 (t1) and 12 months (t2) after inclusion. We used a standardized, validated questionnaire (the European Organisation for Research and Treatment of Cancer Quality of Life Core Instrument (EORTC QLQ-C30) and explored predictors of HRQoL in two populations (all patients (Analysis 1), patients in ongoing complete remission (Analysis 2)) using generalized linear mixed models.ResultsIn total we included up to 1111 patients at baseline (915 at t1, and 847 at t2), thereof 387 participants were in complete remission at baseline (334 at t1, and 200 at t2). When analyzing all patients, HRQoL differed with regard to tumor locations: patients with sarcoma in lower extremities reported lower HRQoL values than patients with sarcomas in the upper extremities. Treatment which included radiotherapy and/or systemic therapy was associated with lower HRQoL. For patients in complete remission, smoking was associated with worse HRQoL-outcomes. In both analyses, bone sarcomas were associated with the worst HRQoL values. Being female, in the age group 55-<65 years, having lower socioeconomic status, and comorbidities were all associated with a lower HRQoL, in both analyses.DiscussionHRQoL increased partially over time since treatment and with sporting activities. HRQoL improved with time since treatment, although not in all domains, and was associated with lifestyle and socioeconomic factors. Bone sarcomas were the most affected subgroup. Methods to preserve and improve HRQoL should be developed for sarcoma patients.
DOI:doi:10.3389/fendo.2023.1166838
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://dx.doi.org/10.3389/fendo.2023.1166838
 kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fendo.2023.1166838
 DOI: https://doi.org/10.3389/fendo.2023.1166838
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1870235258
Verknüpfungen:→ Zeitschrift

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