| |  Online-Ressource |
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| Verfasst von: | Mishra, Richa [VerfasserIn]  |
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| | Hannebelle, Melanie [VerfasserIn] |
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| | Patil, Vishal P. [VerfasserIn] |
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| | Dubois, Anaëlle [VerfasserIn] |
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| | Garcia-Mouton, Cristina [VerfasserIn] |
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| | Kirsch, Gabriela M. [VerfasserIn] |
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| | Jan, Maxime [VerfasserIn] |
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| | Sharma, Kunal [VerfasserIn] |
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| | Guex, Nicolas [VerfasserIn] |
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| | Sordet-Dessimoz, Jessica [VerfasserIn] |
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| | Perez-Gil, Jesus [VerfasserIn] |
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| | Prakash, Manu [VerfasserIn] |
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| | Knott, Graham W. [VerfasserIn] |
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| | Dhar, Neeraj [VerfasserIn] |
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| | McKinney, John D. [VerfasserIn] |
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| | Thacker, Vivek Vijay [VerfasserIn] |
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| Titel: | Mechanopathology of biofilm-like Mycobacterium tuberculosis cords |
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| Verf.angabe: | Richa Mishra, Melanie Hannebelle, Vishal P. Patil, Anaëlle Dubois, Cristina Garcia-Mouton, Gabriela M. Kirsch, Maxime Jan, Kunal Sharma, Nicolas Guex, Jessica Sordet-Dessimoz, Jesus Perez-Gil, Manu Prakash, Graham W. Knott, Neeraj Dhar, John D. McKinney, Vivek V. Thacker |
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| E-Jahr: | 2023 |
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| Jahr: | 20 October 2023 |
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| Umfang: | 16 S. |
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| Fussnoten: | Artikelversion 9. November 2023 ; Gesehen am 16.11.2023 |
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| Titel Quelle: | Enthalten in: Cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1974 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 186(2023), 23, Seite 5135-5150 |
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| ISSN Quelle: | 1097-4172 |
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| Abstract: | Mycobacterium tuberculosis (Mtb) cultured axenically without detergent forms biofilm-like cords, a clinical identifier of virulence. In lung-on-chip (LoC) and mouse models, cords in alveolar cells contribute to suppression of innate immune signaling via nuclear compression. Thereafter, extracellular cords cause contact-dependent phagocyte death but grow intercellularly between epithelial cells. The absence of these mechanopathological mechanisms explains the greater proportion of alveolar lesions with increased immune infiltration and dissemination defects in cording-deficient Mtb infections. Compression of Mtb lipid monolayers induces a phase transition that enables mechanical energy storage. Agent-based simulations demonstrate that the increased energy storage capacity is sufficient for the formation of cords that maintain structural integrity despite mechanical perturbation. Bacteria in cords remain translationally active despite antibiotic exposure and regrow rapidly upon cessation of treatment. This study provides a conceptual framework for the biophysics and function in tuberculosis infection and therapy of cord architectures independent of mechanisms ascribed to single bacteria. |
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| DOI: | doi:10.1016/j.cell.2023.09.016 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cell.2023.09.016 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0092867423010371 |
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| | DOI: https://doi.org/10.1016/j.cell.2023.09.016 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | agent-based model |
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| | antibiotic therapy |
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| | biofilms |
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| | cords |
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| | lung-on-chip |
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| | mechanobiology |
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| | mycomembrane |
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| | serial block scanning face electron microscopy |
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| K10plus-PPN: | 1870436423 |
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| Verknüpfungen: | → Zeitschrift |
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Mechanopathology of biofilm-like Mycobacterium tuberculosis cords / Mishra, Richa [VerfasserIn]; 20 October 2023 (Online-Ressource)
