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| Verfasst von: | Milde, Till [VerfasserIn]  |
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| | Fangusaro, Jason R. [VerfasserIn] |
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| | Fisher, Michael J [VerfasserIn] |
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| | Hawkins, Cynthia [VerfasserIn] |
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| | Rodriguez, Fausto J [VerfasserIn] |
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| | Tabori, Uri [VerfasserIn] |
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| | Witt, Olaf [VerfasserIn] |
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| | Zhu, Yuan [VerfasserIn] |
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| | Gutmann, David H [VerfasserIn] |
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| Titel: | Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation |
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| Verf.angabe: | Till Milde, Jason Fangusaro, Michael J Fisher, Cynthia Hawkins, Fausto J Rodriguez, Uri Tabori, Olaf Witt, Yuan Zhu, and David H Gutmann |
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| E-Jahr: | 2023 |
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| Jahr: | November 2023 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 16.11.2023 ; Online verfügbar: 21. September 2023 |
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| Titel Quelle: | Enthalten in: Neuro-Oncology |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1999 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 25(2023), 11 vom: Nov., Seite 1920-1931 |
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| ISSN Quelle: | 1523-5866 |
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| Abstract: | Pediatric low-grade gliomas (pLGGs) are the most common brain tumor in young children. While they are typically associated with good overall survival, children with these central nervous system tumors often experience chronic tumor- and therapy-related morbidities. Moreover, individuals with unresectable tumors frequently have multiple recurrences and persistent neurological symptoms. Deep molecular analyses of pLGGs reveal that they are caused by genetic alterations that converge on a single mitogenic pathway (MEK/ERK), but their growth is heavily influenced by nonneoplastic cells (neurons, T cells, microglia) in their local microenvironment. The interplay between neoplastic cell MEK/ERK pathway activation and stromal cell support necessitates the use of predictive preclinical models to identify the most promising drug candidates for clinical evaluation. As part of a series of white papers focused on pLGGs, we discuss the current status of preclinical pLGG modeling, with the goal of improving clinical translation for children with these common brain tumors. |
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| DOI: | doi:10.1093/neuonc/noad125 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1093/neuonc/noad125 |
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| | DOI: https://doi.org/10.1093/neuonc/noad125 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1870487648 |
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| Verknüpfungen: | → Zeitschrift |
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Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation / Milde, Till [VerfasserIn]; November 2023 (Online-Ressource)
