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| Verfasst von: | Rössler, Titus [VerfasserIn]  |
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| | Berezhnoy, Georgy [VerfasserIn] |
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| | Singh, Yogesh [VerfasserIn] |
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| | Cannet, Claire [VerfasserIn] |
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| | Reinsperger, Tony [VerfasserIn] |
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| | Schäfer, Hartmut [VerfasserIn] |
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| | Spraul, Manfred [VerfasserIn] |
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| | Kneilling, Manfred [VerfasserIn] |
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| | Merle, Uta [VerfasserIn] |
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| | Trautwein, Christoph [VerfasserIn] |
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| Titel: | Quantitative serum nmr spectroscopy stratifies covid-19 patients and sheds light on interfaces of host metabolism and the immune response with cytokines and clinical parameters |
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| Verf.angabe: | Titus Rössler, Georgy Berezhnoy, Yogesh Singh, Claire Cannet, Tony Reinsperger, Hartmut Schäfer, Manfred Spraul, Manfred Kneilling, Uta Merle and Christoph Trautwein |
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| E-Jahr: | 2022 |
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| Jahr: | 16 December 2022 |
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| Umfang: | 29 S. |
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| Fussnoten: | Gesehen am 21.11.2023 |
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| Titel Quelle: | Enthalten in: Metabolites |
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| Ort Quelle: | Basel : MDPI, 2011 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 12(2022), 12, Artikel-ID 1277, Seite 1-29 |
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| ISSN Quelle: | 2218-1989 |
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| Abstract: | The complex manifestations of COVID-19 are still not fully decoded on the molecular level. We combined quantitative the nuclear magnetic resonance (NMR) spectroscopy serum analysis of metabolites, lipoproteins and inflammation markers with clinical parameters and a targeted cytokine panel to characterize COVID-19 in a large (534 patient samples, 305 controls) outpatient cohort of recently tested PCR-positive patients. The COVID-19 cohort consisted of patients who were predominantly in the initial phase of the disease and mostly exhibited a milder disease course. Concerning the metabolic profiles of SARS-CoV-2-infected patients, we identified markers of oxidative stress and a severe dysregulation of energy metabolism. NMR markers, such as phenylalanine, inflammatory glycoproteins (Glyc) and their ratio with the previously reported supramolecular phospholipid composite (Glyc/SPC), showed a predictive power comparable to laboratory parameters such as C-reactive protein (CRP) or ferritin. We demonstrated interfaces between the metabolism and the immune system, e.g., we could trace an interleukin (IL-6)-induced transformation of a high-density lipoprotein (HDL) to a pro-inflammatory actor. Finally, we showed that metadata such as age, sex and constitution (e.g., body mass index, BMI) need to be considered when exploring new biomarkers and that adding NMR parameters to existing diagnoses expands the diagnostic toolbox for patient stratification and personalized medicine. |
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| DOI: | doi:10.3390/metabo12121277 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/metabo12121277 |
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| | Volltext: https://www.mdpi.com/2218-1989/12/12/1277 |
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| | DOI: https://doi.org/10.3390/metabo12121277 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | biomarker |
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| | glycoprotein |
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| | inflammation |
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| | lipoproteins |
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| | metabolomics |
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| | SARS-CoV-2 |
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| K10plus-PPN: | 1870746449 |
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| Verknüpfungen: | → Zeitschrift |
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Quantitative serum nmr spectroscopy stratifies covid-19 patients and sheds light on interfaces of host metabolism and the immune response with cytokines and clinical parameters / Rössler, Titus [VerfasserIn]; 16 December 2022 (Online-Ressource)
