| Online-Ressource |
Verfasst von: | Dragoš, Anna [VerfasserIn]  |
| Priyadarshini, B. [VerfasserIn]  |
| Hasan, Zahraa [VerfasserIn]  |
| Strube, Mikael Lenz [VerfasserIn]  |
| Kempen, Paul J. [VerfasserIn]  |
| Maróti, Gergely [VerfasserIn]  |
| Kaspar, Charlotte [VerfasserIn]  |
| Bose, Baundauna [VerfasserIn]  |
| Burton, Briana M. [VerfasserIn]  |
| Bischofs-Pfeifer, Ilka [VerfasserIn]  |
| Kovács, Ákos T. [VerfasserIn]  |
Titel: | Pervasive prophage recombination occurs during evolution of spore-forming Bacilli |
Verf.angabe: | Anna Dragoš, B. Priyadarshini, Zahraa Hasan, Mikael Lenz Strube, Paul J. Kempen, Gergely Maróti, Charlotte Kaspar, Baundauna Bose, Briana M. Burton, Ilka B. Bischofs, Ákos T. Kovács |
Jahr: | 2021 |
Umfang: | 15 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Published online: 20 December 2020 ; Gesehen am 23.11.2023 |
Titel Quelle: | Enthalten in: International Society for Microbial EcologyThe ISME journal |
Ort Quelle: | Basingstoke : Nature Publishing Group, 2007 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 15(2021), 5, Seite 1344-1358 |
ISSN Quelle: | 1751-7370 |
Abstract: | Phages are the main source of within-species bacterial diversity and drivers of horizontal gene transfer, but we know little about the mechanisms that drive genetic diversity of these mobile genetic elements (MGEs). Recently, we showed that a sporulation selection regime promotes evolutionary changes within SPβ prophage of Bacillus subtilis, leading to direct antagonistic interactions within the population. Herein, we reveal that under a sporulation selection regime, SPβ recombines with low copy number phi3Ts phage DNA present within the B. subtilis population. Recombination results in a new prophage occupying a different integration site, as well as the spontaneous release of virulent phage hybrids. Analysis of Bacillus sp. strains suggests that SPβ and phi3T belong to a distinct cluster of unusually large phages inserted into sporulation-related genes that are equipped with a spore-related genetic arsenal. Comparison of Bacillus sp. genomes indicates that similar diversification of SPβ-like phages takes place in nature. Our work is a stepping stone toward empirical studies on phage evolution, and understanding the eco-evolutionary relationships between bacteria and their phages. By capturing the first steps of new phage evolution, we reveal striking relationship between survival strategy of bacteria and evolution of their phages. |
DOI: | doi:10.1038/s41396-020-00854-1 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41396-020-00854-1 |
| Volltext: https://www.nature.com/articles/s41396-020-00854-1 |
| DOI: https://doi.org/10.1038/s41396-020-00854-1 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Bacterial genetics |
| Evolution |
K10plus-PPN: | 1871030005 |
Verknüpfungen: | → Zeitschrift |
Pervasive prophage recombination occurs during evolution of spore-forming Bacilli / Dragoš, Anna [VerfasserIn]; 2021 (Online-Ressource)