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Verfasst von:Kercheva, Maria [VerfasserIn]   i
 Ryabov, Vyacheslav [VerfasserIn]   i
 Gombozhapova, Aleksandra [VerfasserIn]   i
 Rebenkova, Maria [VerfasserIn]   i
 Kzhyshkowska, Julia [VerfasserIn]   i
Titel:Macrophages of the "heart-kidney" axis
Titelzusatz:their dynamics and correlations with clinical data and outcomes in patients with myocardial infarction
Verf.angabe:Maria Kercheva, Vyacheslav Ryabov, Aleksandra Gombozhapova, Maria Rebenkova and Julia Kzhyshkowska
E-Jahr:2022
Jahr:18 January 2022
Umfang:11 S.
Fussnoten:Gesehen am 23.11.2023
Titel Quelle:Enthalten in: Journal of Personalized Medicine
Ort Quelle:Basel : MDPI, 2011
Jahr Quelle:2022
Band/Heft Quelle:12(2022), 2, Artikel-ID 127, Seite 1-11
ISSN Quelle:2075-4426
Abstract:Changes in the macrophage infiltration of kidneys in rodents under ischemic conditions may affect cardiac macrophages and lead to development of adaptive cardiac remodeling. The aim of our study was to translate experimental findings into clinically relevant applications and assess the features of macrophage infiltration of the kidney and its correlations with changes in macrophage infiltration of the myocardium and with clinical data in patients who experienced a fatal myocardial infarction (MI). We examined fragments of both organs taken from patients (n = 30) who suffered from fatal MI. Macrophage infiltration was assessed by immunohistochemistry. Macrophage infiltration of the kidneys in patients with fatal MI is heterogeneous. The early period of MI was shown to be characterized by the prevalence of CD163+ and CD68+ cells, and in the long-term period by only CD163+ cells. However, only the level of CD206+ cells in the kidneys showed the dynamics representing the late MI period. Its decrease accompanied increase in the numbers of cardiac CD68+, CD163+, CD206+, and stabilin-1+ cells in the infarct area. Kidney CD206+ cells had more correlations with cardiac macrophages than other cells, and the presence of these cells also correlated with impairment of renal function and early death.
DOI:doi:10.3390/jpm12020127
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/jpm12020127
 kostenfrei: Volltext: https://www.mdpi.com/2075-4426/12/2/127
 DOI: https://doi.org/10.3390/jpm12020127
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cardiac macrophages
 cardiac remodeling
 CD163
 CD206
 CD68
 inflammation
 kidney macrophages
 myocardial infarction
 stabilin-1
K10plus-PPN:1871031362
Verknüpfungen:→ Zeitschrift

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