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| Verfasst von: | Haas, Rick L. M. [VerfasserIn]  |
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| | Stelmes, Jean-Jacques [VerfasserIn] |
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| | Zaffaroni, Facundo [VerfasserIn] |
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| | Sauvé, Nicolas [VerfasserIn] |
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| | Clementel, Enrico [VerfasserIn] |
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| | Bar-Deroma, Raquel [VerfasserIn] |
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| | Le Péchoux, Cécile [VerfasserIn] |
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| | Litière, Saskia [VerfasserIn] |
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| | Marreaud, Sandrine [VerfasserIn] |
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| | Alyamani, Najlaa [VerfasserIn] |
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| | Andratschke, Nicolaus H. J. [VerfasserIn] |
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| | Sangalli, Claudia [VerfasserIn] |
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| | Chung, Peter W. [VerfasserIn] |
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| | Miah, Aisha [VerfasserIn] |
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| | Hurkmans, Coen [VerfasserIn] |
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| | Gronchi, Alessandro [VerfasserIn] |
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| | Bovée, Judith V. M. G. [VerfasserIn] |
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| | Gelderblom, Hans [VerfasserIn] |
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| | Kasper, Bernd [VerfasserIn] |
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| | Weber, Damien Charles [VerfasserIn] |
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| | Bonvalot, Sylvie [VerfasserIn] |
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| Titel: | Critical impact of radiotherapy protocol compliance and quality in the treatment of retroperitoneal sarcomas |
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| Titelzusatz: | results from the EORTC 62092-22092 STRASS trial |
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| Verf.angabe: | Rick Haas, Jean-Jacques Stelmes, Facundo Zaffaroni, Nicolas Sauvé, Enrico Clementel, Raquel Bar-Deroma, Cécile Le Péchoux, Saskia Litière, Sandrine Marreaud, Najlaa Alyamani, Nicolaus H. J. Andratschke, Claudia Sangalli, Peter W. Chung, Aisha Miah, Coen Hurkmans, Alessandro Gronchi, Judith V. M. G. Bovée, Hans Gelderblom, Bernd Kasper, Damien Charles Weber, and Sylvie Bonvalot |
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| E-Jahr: | 2022 |
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| Jahr: | July 15, 2022 |
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| Umfang: | 10 S. |
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| Fussnoten: | First published: 10 May 2022 ; Gesehen am 27.11.2023 |
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| Titel Quelle: | Enthalten in: Cancer |
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| Ort Quelle: | New York, NY : Wiley-Liss, 1948 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 128(2022), 14 vom: Juli, Seite 2796-2805 |
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| ISSN Quelle: | 1097-0142 |
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| Abstract: | Background The European Organization for Research and Treatment of Cancer 22092-62092 STRASS trial failed to demonstrate the superiority of neoadjuvant radiotherapy (RT) over surgery alone in patients with retroperitoneal sarcoma. Therefore, an RT quality-assurance program was added to the study protocol to detect and correct RT deviations. The authors report results from the trial RT quality-assurance program and its potential effect on patient outcomes. Methods To evaluate the effect of RT compliance on survival outcomes, a composite end point was created. It combined the information related to planning target volume coverage, target delineation, total dose received, and overall treatment time into 2 groups: non-RT-compliant (NRC) for patients who had unacceptable deviation(s) in any of the previous categories and RT-compliant (RC) otherwise. Abdominal recurrence-free survival (ARFS) and overall survival were compared between the 2 groups using a Cox proportional hazard model adjusted for known prognostic factors. Results Thirty-six of 125 patients (28.8%) were classified as NRC, and the remaining 89 patients (71.2%) were classified as RC. The 3-year ARFS rate was 66.8% (95% confidence interval [CI], 55.8%-75.7%) and 49.8% (95% CI, 32.7%-64.8%) for the RC and NRC groups, respectively (adjusted hazard ratio, 2.32; 95% CI, 1.25-4.32; P = .008). Local recurrence after macroscopic complete resection occurred in 13 of 89 patients (14.6%) versus 2 of 36 patients (5.6%) in the RC and NRC groups, respectively. Conclusions The current analysis suggests a significant benefit in terms of ARFS in favor of the RC group. This association did not translate into less local relapses after complete resection in the RC group. Multidisciplinary collaboration and review of cases are critical to avoid geographic misses, especially for rare tumors like retroperitoneal sarcoma. |
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| DOI: | doi:10.1002/cncr.34239 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/cncr.34239 |
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| | kostenfrei: Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.34239 |
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| | DOI: https://doi.org/10.1002/cncr.34239 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | protocol compliance |
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| | quality assurance |
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| | radiotherapy |
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| | retroperitoneal sarcomas |
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| | soft tissue sarcomas |
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| K10plus-PPN: | 187131643X |
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| Verknüpfungen: | → Zeitschrift |
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Critical impact of radiotherapy protocol compliance and quality in the treatment of retroperitoneal sarcomas / Haas, Rick L. M. [VerfasserIn]; July 15, 2022 (Online-Ressource)
