| Online-Ressource |
Verfasst von: | Tomaschitz, Andreas [VerfasserIn]  |
| Pilz, Stefan [VerfasserIn]  |
| Ritz, Eberhard [VerfasserIn]  |
| Grammer, Tanja B. [VerfasserIn]  |
| Drechsler, Christiane [VerfasserIn]  |
| Boehm, Bernhard O. [VerfasserIn]  |
| März, Winfried [VerfasserIn]  |
Titel: | Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system |
Titelzusatz: | the Ludwigshafen Risk and Cardiovascular Health (LURIC) study |
Verf.angabe: | Andreas Tomaschitz, Stefan Pilz, Eberhard Ritz, Tanja Grammer, Christiane Drechsler, Bernhard O. Boehm, Winfried März |
E-Jahr: | 2010 |
Jahr: | 1 June 2010 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 28.11.2023 |
Titel Quelle: | Enthalten in: Clinica chimica acta |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1956 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 411(2010), 17/18, Seite 1354-1360 |
ISSN Quelle: | 1873-3492 |
Abstract: | Background - Antihypertensive and tissue-protective properties of vitamin D metabolites are increasingly attributed to the inhibition of renin synthesis by 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney. - Method - We aimed to document a potential association between 25-hydroxyvitamin D [25(OH)D], 1,25(OH)2D and the circulating renin-angiotensin system (RAS) in a large cohort of patients referred (n=3316) to coronary angiography. - Results - Of the 3316 subjects, 3296 (median age: 63.5 (56.3-70.6)years; 30.2% women) had a baseline measurement of 25(OH)D [median: 15.6(10.1-23.0)µg/L)], 1,25(OH)2D [median: 33.2(25.2-42.9)pg/mL], plasma renin concentration [PRC; median: 11.4(6.0-24.6)pg/mL] and angiotensin 2 [median: 20.0(12.0-35.0)ng/L]. Multivariate adjusted ANCOVA showed a steady increase of PRC values across declining deciles of 25(OH)D and 1,25(OH)2D values (P=0.013 and P=0.045), respectively. Additionally, mean angiotensin 2 values increased significantly across decreasing 25(OH)D and 1,25(OH)2D values (P=0.020 and P=0.024, respectively). In contrast, multivariate adjusted ANCOVA revealed no significant associations between aldosterone, aldosterone-to-renin ratio and 25(OH)D/1,25(OH)2D values. In multivariate stepwise regression analyses both, 25(OH)D and 1,25(OH)2D emerged as independent predictors of plasma renin and angiotensin 2 concentrations. - Conclusions - Our data showed for the first time in humans that both, lower 25(OH)D and 1,25(OH)2D values are independently related to an upregulated circulating RAS. |
DOI: | doi:10.1016/j.cca.2010.05.037 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cca.2010.05.037 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0009898110003700 |
| DOI: https://doi.org/10.1016/j.cca.2010.05.037 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Renin-angiotensin system |
| Vitamin D |
K10plus-PPN: | 1871444314 |
Verknüpfungen: | → Zeitschrift |
Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system / Tomaschitz, Andreas [VerfasserIn]; 1 June 2010 (Online-Ressource)