How to plan and manage an individual participant data meta-analysis

• Verfasst von: Maxwell, Lauren [VerfasserIn]
• Verfasst von: Shreedhar, Priya [VerfasserIn]
• Verfasst von: Carabali, Mabel [VerfasserIn]
• Verfasst von: Levis, Brooke [VerfasserIn]
• Titel: How to plan and manage an individual participant data meta-analysis
• Titelzusatz: an illustrative toolkit
• Verf.angabe: Lauren Maxwell, Priya Shreedhar, Mabel Carabali, Brooke Levis
• Jahr: 2023
• Umfang: 9 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht: 12. September 2023 ; Gesehen am 28.11.2023
• Titel Quelle: Enthalten in: Research synthesis methods
• Ort Quelle: Hoboken, NJ [u.a.] : Wiley, 2010
• Jahr Quelle: 2023
• Band/Heft Quelle: (2023), online ahead of print
• ISSN Quelle: 1759-2887
• DOI: doi:10.1002/jrsm.1670
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: individual participant data meta-analysis (IPD-MA)
• Sach-SW: IPD-MA management
• Sach-SW: project management
• Sach-SW: templates
• Sach-SW: toolkit
• K10plus-PPN: 1871459710

Abstract

Individual participant data meta-analyses (IPD-MAs) have several benefits over standard aggregate data meta-analyses, including the consideration of additional participants, follow-up time, and the joint consideration of study- and participant-level heterogeneity for improved diagnostic and prognostic model development and evaluation. However, IPD-MAs are resource-intensive and require careful budgeting of time from data contributing groups, a dedicated management team, diversity of expertise, clearly documented data sharing and authorship agreements, and consistent and clear communication. We present a toolkit to facilitate the implementation and management of IPD-MAs, from study recruitment to retrospective harmonization. The toolkit was developed and refined over our work on multiple multinational IPD-MA projects over the last 13 years. The toolkit's budget and email templates, agreements, project management spreadsheets, and standard operating procedures are meant to facilitate routine IPD-MA tasks to expedite implementing and managing future IPD-MA projects.