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| Verfasst von: | Jungbauer, Frederic [VerfasserIn]  |
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| | Gerhards, Catharina [VerfasserIn] |
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| | Thiaucourt, Margot [VerfasserIn] |
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| | Behnes, Michael [VerfasserIn] |
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| | Rotter, Nicole [VerfasserIn] |
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| | Schell, Angela [VerfasserIn] |
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| | Haselmann, Verena [VerfasserIn] |
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| | Neumaier, Michael [VerfasserIn] |
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| | Kittel, Maximilian [VerfasserIn] |
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| Titel: | Anosmia testing as early detection of SARS-CoV-2 positivity |
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| Titelzusatz: | a prospective study under screening conditions |
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| Verf.angabe: | Frederic Jungbauer, Catharina Gerhards, Margot Thiaucourt, Michael Behnes, Nicole Rotter, Angela Schell, Verena Haselmann, Michael Neumaier and Maximilian Kittel |
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| E-Jahr: | 2022 |
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| Jahr: | 28 June 2022 |
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| Umfang: | 16 S. |
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| Fussnoten: | Dieser Artikel gehört zum Special issue: Olfactory and gustatory dysfunctions in COVID‐19 patients ; Gesehen am 28.11.2023 |
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| Titel Quelle: | Enthalten in: Life |
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| Ort Quelle: | Basel : MDPI, 2011 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 12(2022), 7, Artikel-ID 968, Seite 1-16 |
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| ISSN Quelle: | 2075-1729 |
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| Abstract: | Sudden onset of anosmia is a phenomenon often associated with developing COVID-19 disease and has even been described as an initial isolated symptom in individual cases. In this case-control study, we investigated the feasibility of this condition as a suitable screening test in a population at risk. We performed a prospective study with a total of 313 subjects with suspected SARS-CoV-2 infection. In parallel to routine PCR analysis, a modified commercial scent test was performed to objectify the presence of potential anosmia as a predictor of SARS-CoV-2 positivity. Furthermore, a structured interview assessment of the participants was conducted. A total of 12.1% of the study participants had molecular genetic detection of SARS-CoV-2 infection in the nasopharyngeal swab. It could be demonstrated that these subjects had a significantly weaker olfactory identification performance of the scents. Further analysis of the collected data from the scent test and medical history via random forest (Boruta) algorithm showed that no improvement of the prediction power was achieved by this design. The assay investigated in this study may be suitable for screening general olfactory function. For the screening of COVID-19, it seems to be affected by too many external and internal biases and requires too elaborate and selective pre-test screening. |
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| DOI: | doi:10.3390/life12070968 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/life12070968 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2075-1729/12/7/968 |
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| | DOI: https://doi.org/10.3390/life12070968 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | anosmia |
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| | Boruta algorithm |
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| | case-control-study |
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| | COVID-19 |
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| | olfactory dysfunction |
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| | prediction model |
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| | screening-test |
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| K10plus-PPN: | 1871461820 |
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| Verknüpfungen: | → Zeitschrift |
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Anosmia testing as early detection of SARS-CoV-2 positivity / Jungbauer, Frederic [VerfasserIn]; 28 June 2022 (Online-Ressource)
